Pharm

Progestin Androgenic Activity

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Progestin Androgenic Activity, Androgenic Activity

  • General
  1. Unbound testosterone increases with androgenicity
  • Characteristics
  1. Conditions associated with high Androgenic Activity
    1. Acne Vulgaris
    2. Hirsutism
    3. Polycystic Ovary Syndrome (PCOS)
    4. Obesity (or weight gain)
    5. Nervousness
    6. Lowered HDL-2
  2. Conditions associated with low Androgenic Activity
    1. Decreased libido
  • Progestins with most potent Androgenic Activity
  1. Methyltestosterone (50): Upper limit reference
  2. Gestodene (8.6)
  3. Levonorgestrel (8.3)
  4. dl-Norgestrel (4.2)
  5. Desogestrel (3.4)
  • Progestins with least Androgenic Activity
  1. Pregnane Progestin (0)
  2. Norethynodrel (0)
  3. Ethynodiol Diacetate (0.6)
  4. Norethindrone (1.0): Lower limit reference
  • Oral Contraceptive Androgenic Activity (low to high)