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BRCA1

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BRCA1

  • Location
  • Epidemiology
  1. More common in Ashkenazi Jewish women
  2. Does not affect males (unlike BRCA2)
  3. Responsible for a third of hereditary Breast Cancer
  4. Defective gene connotes:
    1. Ovarian Cancer risk: 40-60%
    2. Breast Cancer risk: 90%
      1. Age 20-29: Relative Risk Breast Cancer 106
      2. Age 30-39 Relative Risk Breast Cancer 44
      3. Age 40-49: Relative Risk Breast Cancer 15
      4. Age 50-59: Relative Risk Breast Cancer 8.2
      5. Age 60-69: Relative Risk Breast Cancer 2.8
      6. Chen (2006) j clin oncol 24(6): 863-71 [PubMed]
      7. Metcalfe (2018) Clin Genet 93(5): 1063-8 [PubMed]