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BRCA1

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BRCA1

  • Location
  • Epidemiology
  1. Defective gene connotes:
    1. Breast Cancer risk: 90%
    2. Ovarian Cancer risk: 40-60%
  2. More common in Ashkenazi Jewish women
  3. Does not affect males
  4. Responsible for a third of hereditary Breast Cancer
  • Availability
  • Soon to be commercially available
  1. U of Pennsylvania Medical Center in Philadelphia
  2. Myriad Genetics in Salt Lake City, Utah
  • Cost
  1. First Family Member: $670
  2. Each additional family member (if first positive): $250
  • Efficacy
  1. Sensitivity: 85-90%