Microscopic Colitis


Microscopic Colitis, Lymphocytic Colitis, Collagenous Colitis

  • See Also
  • Epidemiology
  1. More common in older patients (age 50 years old and older)
  2. Causes 10% of Chronic Diarrhea cases
  • Risk Factors
  • Medications
  • Symptoms
  1. Typical presentation is nocturnal Diarrhea in older patient, and not better with Fasting
  • Labs
  1. Stool studies without microscopic blood or mucus
  • Associated Conditions
  1. Celiac Sprue (5% of cases)
  1. Normal gross appearance
  2. Biopsy of transverse colon confirms diagnosis with one of two histologic patterns
    1. Lymphocytic Colitis
      1. Lamina propria with lymphocytic infiltrate
    2. Collagenous Colitis
      1. Subepithelial collagen layer increased >10mm