Pharm
Intranasal Drug Delivery Route
search
Intranasal Drug Delivery Route
, Intranasal Medication Route, Intranasal Route of Medication Delivery
See Also
Procedural Sedation and Analgesia
Indications
Procedural Sedation and Analgesia
Difficult Intravenous Access in Children
Laceration Repair
Lumbar Puncture
Mechanism
Nasal mucosa is well vascularized with rapid medication absorption
Ideal intranasal medications are lipophilic and small in molecular size
Intranasal medications are best tolerated and absorbed at pH 4.5 to 6.5
Maximal amount that may be absorbed intranasally is 0.3 ml
Typical drug delivery is via a Mucosal Atomization Device (MAD Atomizer)
Device has 0.1 ml dead space (draw up extra 0.1 ml medication)
Preparations
Intranasal medications for analgesia and sedation
See
Procedural Sedation and Analgesia
for dosing
Analgesia
Fentanyl
Ketamine
Lidocaine
Sedation
Midazolam
(
Versed
)
Dexmedetomidine
(
Precedex
)
Type your search phrase here