Allergy

Allergic Triad

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Allergic Triad, Aspirin Induced Asthma, Aspirin Allergy

  • Definition
  1. Allergic constellation centered around Aspirin Allergy
  • Associated Conditions
  1. Aspirin-induced Asthma
  2. Rhinorrhea
  3. Nasal Polyps
  4. Chronic Sinusitis
  5. Conjunctival edema
  • Course
  1. Onset as perennial Vasomotor Rhinitis
  2. Develops into hyperplastic Rhinosinusitis, Nasal Polyps
  • Causes
  1. Aspirin
  2. Cross-reactivity with NSAIDs
    1. Indomethacin
    2. Naproxen
    3. Ibuprofen
    4. Fenoprofen
    5. Mefenamic acid
    6. Phenylbutazone
  • Management
  1. Avoid Aspirin and causative NSAIDs above
  2. Use safe alternative Analgesics instead
    1. Salsalate
    2. Acetaminophen
  3. Treat Aspirin-induced Asthma
    1. Leukotriene modifiers (e.g. Sinulair)