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Azelaic Acid

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Azelaic Acid, Azelex

  • Indication
  • Mechanism
  1. Topical antibacterial, Keratolytic agent
  • Efficacy
  1. Not as effective as originally thought
  2. Only mild effect
  3. Use as an adjunct to other treatment
  • Dosing
  1. Apply twice daily
  2. Cream 20% (Azelex)
    1. Approved for Acne Vulgaris
  3. Gel 15% (Finacea)
    1. Approved for Acne Rosacea
    2. Much better bioavailability than Azelex
  • Adverse Effects
  1. Hypopigmentation
  2. Less irritating than Tretinoin or Benzoyl Peroxide
  3. Pruritus
  4. Burning, stinging and tingling
  5. Local erythema
  • Precautions
  1. Use caution in Acne Vulgaris patients with dark skin
  2. May cause Hypopigmentation
  • Safety
  1. Pregnancy Category B
    1. Only category B Keratolytic agent