Cardiovascular Medicine Book


Creatine Phosphokinase

Aka: Creatine Phosphokinase, Creatine Kinase, Creatine Phosphotransferase, CPK, CK-MB, CK-MM ( C0010291), CK-BB
  1. See Also
    1. Serum Cardiac Markers
  2. Physiology
    1. Transferase class enzyme activated by Magnesium
    2. Catalyzes ATP energy storage as Phosphocreatine
    3. Phosphocreatine stored in Muscle and brain
    4. Phosphocreatine keeps ATP constant at Exercise start
  3. Increased
    1. Myocardial Infarction
    2. Myocarditis
    3. Rhabdomyolysis
    4. Myositis
    5. Crush injury or Trauma
    6. Dermatomyositis or Polymyositis
    7. Muscular Dystrophy
    8. Myxedema (Hypothyroidism)
    9. Seizure
    10. Malignant Hyperthermia
    11. Intramuscular Injections
    12. Cerebrovascular Accident
    13. Pulmonary Infarction
    14. Pulmonary Embolus
    15. Acute Aortic Dissection
    16. Vigorous Exercise
      1. CPK levels increase with common exertional activities (e.g. >20x normal at 1 day after marathon)
      2. Siegel (1981) JAMA 246(18): 2049-51 +PMID: 7288991 [PubMed]
      3. Kenney (2012) Muscl Nerve 45(30: 356-62 +PMID:22334169 [PubMed]
      4. Clarkson (2006) Med Sci Sports Exerc 38(4): 623-7 +PMID:16679975 [PubMed]
  4. Isoenzymes:
    1. MB: Heart
    2. MM: Skeletal Muscle
    3. BB:
      1. Brain
      2. Bowel infarction
      3. Neoplasm (Prostate, GI, Breast, Ovary, Lung, Brain)
  5. Protocol: Acute Coronary Syndrome Evaluation (listed for historical reasons)
    1. Older protocol - replaced in United States with Troponin
    2. Obtain Serial CPK every 6 hours for total of 3 values
    3. Fractionate to CK-MB only if CPK increased
    4. CK-MB >5% of total CPK suggests Myocardial Infarction

Creatine Kinase (C0010287)

Definition (NCI) An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.
Definition (MSH) A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D003402
SnomedCT 75828004
LNC LP15510-8, MTHU006937
English ADP Phosphocreatine Phosphotransferase, ATP Creatine Phosphotransferase, Creatine Kinase, Creatine Phosphokinase, Creatine Phosphotransferase, ATP, Kinase, Creatine, Phosphocreatine Phosphotransferase, ADP, Phosphokinase, Creatine, Phosphotransferase, ADP Phosphocreatine, Phosphotransferase, ATP Creatine, creatine kinase, ATP:creatine N-phosphotransferase, Creatine Kinase [Chemical/Ingredient], creatine kinase (CK), creatine phosphokinase (CPK), creatine phosphokinase, Phosphocreatine Kinase, ATP:Creatine N-Phosphotransferase, Creatine Phosphotransferase, CPK, CK, Adenosine Triphosphate-Creatine Transphosphorylase, ATP:Creatine Phosphotransferase, Creatine kinase, Creatine phosphokinase, CK - Creatine kinase, CPK - Creatine phosphokinase, Creatine kinase (substance)
Swedish Kreatinkinas
Czech kreatinfosfokinasa, kreatinkináza, kreatinkinasa
Finnish Kreatiinikinaasi
Japanese クレアチンキナーゼ, クレアチンホスホキナーゼ, ローマン酵素
Italian ADP fosfocreatina fosfotransferasi, ATP creatina fosfotransferasi, Creatina fosfochinasi, Creatinchinasi
Polish Fosfokinaza kreatynowa, Kinaza fosfokreatynowa, Kinaza kreatynowa
Portuguese Creatinoquinase, Creatina Fosfoquinase, Creatina Quinase
Spanish creatina cinasa (sustancia), creatina cinasa, creatina fosfocinasa, creatincinasa, creatinquinasa, Creatina Fosfoquinasa, Creatina Quinasa
French CPK, Creatine kinase, ATP créatine N-phosphotransférase, Créatine phosphokinase
German Creatin-Kinase, Creatinkinase-Isoenzyme, Creatinkinase-Isozyme, Creatinphosphokinase, Kreatinase-Isoenzyme, Kreatinase-Isozyme, Kreatinase, Kreatinphosphokinase, Creatinkinase, Kreatinkinase, Kreatinkinase-Isoenzyme
Derived from the NIH UMLS (Unified Medical Language System)

Creatine Kinase, BB Form (C0010289)

Definition (MSH) A form of creatine kinase found in the BRAIN.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D052276
SnomedCT 66128009
English CKBB-Creatine kinase BB isoenz, Creatine kinase isoenzyme, CK1 fraction, Creatine kinase isoenzyme, CK<sub>1</sub> fraction, Creatine Kinase, BB Form [Chemical/Ingredient], ck bb, Creatine kinase isoenzyme, BB fraction, CKBB - Creatine kinase BB isoenzyme, Creatine kinase BB isoenzyme, Creatine kinase isoenzyme, CK>1< fraction, Creatine kinase isoenzyme, BB fraction (substance), BB Creatine Kinase, Brain Creatine Kinase, Creatine Kinase, BB, Creatine Kinase, Brain, Kinase, BB Creatine, Kinase, Brain Creatine, Creatine Kinase, BB Form
Spanish Forma BB de la Creatina-Quinasa, isoenzima de creatinquinasa, fracción CK<sub>1</sub>, isoenzima de creatinquinasa, fracción CK1, Forma BB de la Creatina-Cinasa, Forma BB de la Creatincinasa, isoenzima de creatina cinasa, fracción BB (sustancia), isoenzima de creatina cinasa, fracción BB, isoenzima de creatinquinasa, fracción CK>1<
Italian Creatina chinasi, forma BB, Creatina chinasi del cervello, Creatina chinasi BB
Swedish Kreatinkinas, BB
Czech kreatinkinasa - forma BB, kreatinkinasa - isoenzym BB
Finnish CK-BB
Polish Kinaza kreatyninowa forma BB
Japanese 脳クレチンキナーゼ, BB型クレアチンキナーゼ, クレチンキナーゼ-脳, クレアチンキナーゼ-BB型
Portuguese Creatina Quinase Forma BB
German BB-Kreatinkinase, Gehirn-Kreatinkinase, Kreatinkinase, BB-Form
French BB Creatine kinase, Brain creatine kinase, CK-BB, CPK-BB, Créatine kinase du cerveau, Créatine kinase-BB, Créatine phosphokinase du cerveau, Isoenzyme CKBB, Isoenzyme CPK-BB
Derived from the NIH UMLS (Unified Medical Language System)

Creatine Kinase MB Isoenzyme (C0010290)

Definition (MSH) An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D052279
SnomedCT 12016004
LNC LP32033-0, LP15513-2, MTHU003587
English CKMB-Creatine kinase MB isoenz, Creatine kinase isoenzyme, CK2 fraction, Creatine kinase isoenzyme, CK<sub>2</sub> fraction, Creatine Kinase MB Isoenzyme, Creatine Kinase, MB Form [Chemical/Ingredient], ck mb, Creatine kinase.MB, Creatine kinase isoenzyme, MB fraction, CKMB - Creatine kinase MB isoenzyme, Creatine kinase MB isoenzyme, Creatine kinase isoenzyme, CK>2< fraction, Creatine kinase isoenzyme, MB fraction (substance), CPK-MB, Isoenzyme, Creatine Kinase, MB Form, Isoenzyme CPK-MB, Isoenzyme CPK MB, Creatine Kinase, MB, Kinase, MB Creatine, Kinase, Myocardial Creatine, MB Creatine Kinase, Myocardial Creatine Kinase, Creatine Kinase, Myocardial
Spanish Forma MB de la Creatina-Quinasa, isoenzima de creatinquinasa, fracción CK2, isoenzima de creatinquinasa, fracción CK<sub>2</sub>, Forma MB de la Creatina-Cinasa, Forma MB de la Creatincinasa, isoenzima de creatina cinasa, fracción MB (sustancia), isoenzima de creatina cinasa, fracción MB, isoenzima de creatinquinasa, fracción CK>2<
Italian Creatina chinasi, forma MB, Creatina chinasi MB, Creatina chinasi miocardica, Isoenzima CPK-MB
Swedish Kreatinkinas, MB
Czech isoenzym CPK-MB, kreatinkinasa - isoenzym MB, kreatinkinasa - forma MB
Finnish CK-MB
Polish Kinaza kreatyninowa forma MB
Japanese 心筋クレアチンキナーゼ, MB型クレアチンキナーゼ, クレアチンキナーゼ-MB型, クレアチンキナーゼ-心筋
Portuguese Creatina Quinase Forma MB
German Isoenzym CPK-MB, Kreatinkinase, MB-Form, MB-Kreatinkinase, Myokardiale Kreatinkinase
French CK-MB, CPK-MB, Créatine kinase du myocarde, Créatine kinase-MB, Créatine phosphokinase du myocarde, Isoenzyme CKMB, Isoenzyme CPK-MB, MB Creatine kinase, Myocardial creatine kinase
Derived from the NIH UMLS (Unified Medical Language System)

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