Urology Book

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Gonadotoxin

Aka: Gonadotoxin, Medications that Impair Male Fertility
  1. See Also
    1. Infertility
    2. Impotence due to Medication
  2. Causes: Drug or toxin use
    1. Nicotine or Tobacco use or Passive Smoke Exposure
    2. Alcohol Abuse
    3. Anabolic Steroids
    4. Antiandrogens
    5. Cocaine
    6. Marijuana use
    7. Opioids
    8. Toxin exposure
      1. Heavy metal exposure
      2. Organic solvents and Pesticides
      3. Radiation exposure
      4. Alkylating Agents
  3. Causes: Other medications
    1. Allopurinol
    2. Colchicine
    3. Chemotherapy
    4. Cimetidine
    5. Corticosteroids
    6. Cyclosporine
    7. Diltiazem
    8. Erythromycin
    9. Gentamicin
    10. Methotrexate
    11. Neomycin
    12. Nifedipine
    13. Nitrofurantoin
    14. Opioids
    15. Tetracycline
    16. Spironolactone
    17. Sulfasalazine
    18. Ketoconazole
  4. Causes: Possible Effects (need further study)
    1. Ibuprofen
      1. May decrease sex hormones
      2. However has not been shown to cause inferility, lower testosterone or decreased Sperm Count
      3. Kristensen Proc (2018) Natl Acad Sci U S A 115(4):E715-E724 +PMID: 29311296 [PubMed]
  5. References
    1. Kolettis (2003) Am Fam Physician 67(10):2165-72 [PubMed]

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