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Thrombin Hemostatic
Aka: Thrombin Hemostatic, Topical Thrombin, Topical Thrombin in Gelatin, Floseal
- See Also
- Topical Hemostatic Agent
- Indications
- Control of minor bleeding (e.g. tongue Laceration) in patients with prolonged INR (e.g. Warfarin)
- Used in combination with gelatins
- Mechanism
- Topical Hemostatic Agent
- Thrombin facilitates Fibrinogen conversion to Fibrin in the formation of clot
- Preparations
- Bovine-derived Thrombin (Thrombin-JMI)
- Contraindicated in cow allergies
- Human plasma-derived Thrombin (Evithrom)
- Recombinant human Thrombin (rhThrombin)
- Topical Thrombin in Gelatin (Floseal)
- References
- Berry in Schrage (2013) Topical Hemostatic Agents, Medscape Emedicine
- Peralta in Sanfrey (2013) Overview of Topical Hemostatic Agents and tissues adhesives used in the operating room, UpToDate, Wolters-Kluwer
- Achneck (2010) Ann Surg 251(2):217-28 [PubMed]