Rheumatology Book


Bone Turnover Biochemical Marker

Aka: Bone Turnover Biochemical Marker, Bone Remodeling Chemical Marker
  1. See Also
    1. Bone Densitometry
    2. Bone Physiology
  2. Indications (used more as a research tool currently)
    1. Monitor peri-menopausal and postmenopausal bone loss
    2. Monitor treatment outcomes
  3. Labs: Bone formation (Serum markers)
    1. Alkaline Phosphatase (total)
    2. Alkaline Phosphatase (skeletal isoenzymes)
    3. Procollagen-I Extension peptide
    4. Osteocalcin
  4. Labs: Bone resorption (most are urine markers)
    1. Urine Calcium
    2. Urine hydroxyproline
    3. Serum type I Collagen breakdown product (serum CTX)
    4. Collagen cross-link fragments (first to be hydrolyzed)
      1. Urine Total pyridinoline
      2. Urine Free deoxypyridinoline
      3. Urine N-Telopeptide (n-terminus of Collagen fibril)
      4. Urine C-Telopeptide (c-terminus of Collagen fibril)
  5. References
    1. Rosen (1998) Postgrad Med 104(4):101-14 [PubMed]

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