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Polymyositis Evaluation
Aka: Polymyositis Evaluation, Dermatomyositis Evaluation
- See Also
- Polymyositis
- Dermatomyositis
- Labs: Muscle Enzymes
- Serum Aldolase
- Alanine Aminotransferase (ALT)
- Aspartate Aminotransferase (AST)
- Lactate Dehydrogenase (LDH)
- Creatine Phosphokinase (CPK)
- Carbonic Anhydrase (isoenzyme III)
- Limited availability
- Lab: Rheumatologic
- Erythrocyte Sedimentation Rate (ESR)
- Increased in 50% of cases
- Poor correlation with disease activity
- Rheumatoid Factor
- Increased in 20% of cases
- Associated with overlap syndrome
- Antinuclear Antibody (ANA)
- Seen in 80% of Dermatomyositis and Polymyositis patients
- Labs: Specific Autoantibodies
- Anti-Jo1
- Seen in 20% of Dermatomyositis
- Anti-EJ
- Associated with Dermatomyositis
- Signal Recognition Particle (SRP)
- Seen in 5% of Polymyositis
- Associated in severe, acute-onset Polymyositis
- Treatment resistant Dermatomyositis, Polymyositis
- Associated with cardiac involvement
- Anti-Mi2
- Seen in 15-20% of classic Dermatomyositis
- Associated conditions
- Treatment-responsive form
- Shawl sign in Dermatomyositis
- Prominent cuticular changes
- Anti-PM-Scl
- Seen in overlap syndrome
- Associated conditions
- Dermatomyositis and Polymyositis
- Scleroderma
- Anti-Ku
- Seen in overlap syndrome
- Associated conditions
- Dermatomyositis and Polymyositis
- Scleroderma
- Systemic Lupus Erythematosus
- Labs: Juvenile Dermatomyositis
- Neopterin
- Factor VIII-related Antigen (Von Willebrand Factor)
- Diagnostics: Electromyogram (EMG)
- False Negative in 10% of cases
- Myopathic or myogenic pattern
- Short duration, polyphasic motor unit potentials
- Spontaneous fibrillation potentials
- Monitoring: Ovarian Cancer Screening in Women
- Initial gynecologic exam and every 6-12 months x2 years
- Baseline CA-125 level
- Baseline Mammogram
- Baseline Transvaginal Ultrasound of the ovaries
- References
- Ioannou (1999) Curr Opin Rheumatol 11(6):468-74 [PubMed]
- Koler (2001) Am Fam Physician 64(9):1565-72 [PubMed]
- Pachman (1995) Pediatr Clin North Am 42:1071-98 [PubMed]
- Sigurgeirsson (1992) N Engl J Med 326:363-7 [PubMed]
- Whitmore (1994) Medicine 73:153-60 [PubMed]