//fpnotebook.com/
Sodium Zirconium Cyclosilicate
Aka: Sodium Zirconium Cyclosilicate, Zirconium Cyclosilicate, Lokelma
- See Also
- Hyperkalemia
- Patiromer (Veltassa)
- Kayexalate (Sodium Polystyrene Sulfonate)
- Indications
- Chronic Hyperkalemia
- Often used to allow continuation of ACE Inhibitors or ARB Agents despite elevated Serum Potassium
- Considered in Systolic Dysfunction, recent MI and Chronic Kidney Disease
- Efficacy
- Not effective or indicated in acute, life threatening Hyperkalemia
- Mechanism
- Exchanges Sodium to bind Potassium and hydrogen in the Gastrointestinal Tract
- Passes through the Gastrointestinal Tract without absorption
- Advantages
- Decreased gastrointestinal effects when compared with Kayexalate
- Disadvantages
- Very expensive ($25/day in 2019)
- Hypomagnesemia risk
- Edema risk
- Precautions
- Valtessa is preferred (less edema risk)
- Consider other measures to reduce Serum Potassium
- Avoid Dietary Potassium
- Avoid other medications that raise Potassium (e.g. Septra, NSAIDs)
- Consider adding Diuretic (e.g. Furosemide)
- References
- (2019) Presc Lett 26(4): 23