Nephrology Book

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Drug Interactions due to Chelating Cations

Aka: Drug Interactions due to Chelating Cations, Chelating Cation, Cation Binding
  1. Definitions
    1. Charged elements that bind drugs in the intestinal tract and prevent absorption
  2. Mechanism
    1. Multivalent cations bind medications and form insoluble complexes that cannot be absorbed across gut
  3. Causes: Cations
    1. Aluminum (e.g. amphojel)
    2. Magnesium (e.g. Magnesium Oxide, Magnesium Citrate)
    3. Aluminum-Magnesium Combinations (e.g. maalox)
    4. Calcium (e.g. Tums)
    5. Iron (e.g. iron supplements)
  4. Drug Interactions: Decreased Absorption when Cations present
    1. Tetracyclines
    2. Fluoroquinolones
    3. Thyroid medications (e.g. Synthroid)
  5. Management
    1. Administer medications 2 hours before or 6 hours after cation containing agents
  6. References
    1. Carpenter (2019) Am Fam Physician 99(9): 558-64 [PubMed]

cation binding (C1523815)

Definition (GO) Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. [GOC:jl]
Concepts Molecular Function (T044)
English cation binding
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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