Nephrology Book


Uric Acid

Aka: Uric Acid
  1. Physiology
    1. Uric Acid is a metabolic-by-product of Purine catabolism
    2. Uricase converts Uric Acid to allantoin in most mammals, but is dysfunctional in humans
    3. Uric Acid varies considerably with Purine and Alcohol intake, as well as Renal Function
  2. Interpretation: Normal
    1. Uric Acid: 2-7 mg/dl
  3. Interpretation: Increased (Hyperuricemia)
    1. See Hyperuricemia
  4. Interpretation: Decreased
    1. Medications
      1. Allopurinol
      2. High dose ASA
      3. Probenecid
      4. Coumadin
      5. Corticosteroids
    2. SIADH
    3. Renal tubule disease (Fanconi Syndrome)
    4. Liver disease
    5. Alcohol
    6. Wilson's Disease
    7. Hemochromatosis
    8. Protein or Purine deficient diet
    9. Xanthine-oxidase deficiency

Uric Acid (C0041980)

Definition (NCI_NCI-GLOSS) A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side effect of chemotherapy or radiation therapy.
Definition (NCI) A white tasteless odorless crystalline product of protein metabolism, found in the blood and urine, as well as trace amounts found in the various organs of the body. It can build up and form stones or crystals in various disease states.
Definition (MSH) An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Definition (ALT) Uric acid.
Concepts Biologically Active Substance (T123) , Organic Chemical (T109)
MSH D014527
SnomedCT 1710001
English 2,6,8-Trihydroxypurine, Acid, Uric, Trioxopurine, Uric Acid, 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, Uric Acid [Chemical/Ingredient], uric acid, 2,6,8-Trioxopurine, 7,9-Dihydro-1H-purine-2,6,8(3H)-trione, 1H-Purine-2,6,8-triol, 2,6,8-Trioxypurine, URIC ACID, Uric acid, UA - Uric acid, Uric acid (substance), Uric acid, NOS, Uricum acidum / uric acid, uricum acidum/uric acid
Swedish Urinsyra
Czech kyselina močová
Finnish Virtsahappo
Japanese 尿酸
Spanish Ácido Úrico, ácido úrico (sustancia), ácido úrico
Polish Kwas moczowy
French Acide urique, Urique, acide
German Harnsäure
Italian Acido urico
Portuguese Ácido Úrico
Derived from the NIH UMLS (Unified Medical Language System)

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