Nephrology Book


Poststreptococcal Glomerulonephritis

Aka: Poststreptococcal Glomerulonephritis, Post-Streptococcal Glomerulonephritis
  1. See Also
    1. Acute Glomerulonephritis
  2. Epidemiology
    1. Most common cause of Glomerulonephritis
    2. Most often in childhood (ages 2 to 6)
  3. Pathophysiology
    1. Prototype for Acute Glomerulonephritis
    2. Follows Group A Beta Hemolytic Streptococcus Infection
    3. Onset 10-14 days after infection
      1. Streptococcal Pharyngitis
      2. Scarlet Fever
  4. Symptoms: Nephritic Syndrome
    1. Oliguric Acute Renal Failure
    2. Gross Hematuria
    3. Flank pain is variably present
    4. General symptoms
      1. Headache
      2. Anorexia
      3. Nausea or Vomiting
  5. Signs
    1. Hypertension
    2. Edema
  6. Labs
    1. Throat Culture
    2. Skin Culture
    3. ASO Titer increased on serial measurements
    4. Serum Complement decreased
  7. Diagnosis: Renal biopsy
    1. Indications: Diffuse proliferative Glomerulonephritis
      1. Severe or progressive Renal Failure
      2. Delayed resolution of clinical illness
      3. Systemic signs (Joint Pain, fever, Hepatomegaly)
  8. Prognosis
    1. Most cases are self limited (95%)
      1. Resolve within 4 weeks without residua
    2. Adults do worse then children
      1. Higher risk of Chronic Glomerulonephritis

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