Nephrology Book


Nephrogenic Diabetes Insipidus

Aka: Nephrogenic Diabetes Insipidus, Nephrogenic DI
  1. See Also
    1. Central Diabetes Insipidus
    2. Antidiuretic Hormone
  2. Pathophysiology
    1. Deficient response by Kidney to Antidiuretic Hormone (ADH)
      1. Contrast with Central Diabetes Insipidus (deficient ADH)
    2. ADH fails increasing collecting duct water permeability
    3. Failed countercurrent mechanism
      1. Inadequate generation of hypertonic interstitium
  3. Causes
    1. Congenital
    2. Chronic disease of renal Medulla
      1. Medullary cystic disease
      2. Pyelonephritis
    3. Protein deficient diet
    4. Salt deficient diet
    5. Hypercalcemia
    6. Hypokalemia
    7. Amyloidosis
    8. Multiple Myeloma
    9. Medications
      1. Demeclocycline
      2. Lithium
      3. Glyburide
  4. Diagnosis
    1. Fluid Deprivation Test
      1. No response to water deprivation
      2. No response to exogenous ADH administration
    2. Hare-Hickey Test
      1. Increased ADH to Serum Osmolality ratio

Nephrogenic Diabetes Insipidus (C0162283)

Definition (MSH) A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Definition (NCI) Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone.
Definition (CSP) polyuric disorder characterized by normal rates of renal filtration and solute excretion, but a persistent hypotonic urine due to the failure of renal tubules to respond to antidiuretic hormones, such as vasopressin, to reduce urine volume; tubular insensitivity to vasopressin can result from genetic defects, diseases, drug effects, or may occur with pregnancy.
Concepts Disease or Syndrome (T047)
MSH D018500
ICD9 588.1
ICD10 N25.1
SnomedCT 123294004, 111395007
English DIABETES INSIPIDUS NEPHROGENIC, Diabetes Insipidus, Nephrogenic, NDI - Nephrogen diab insipidus, nephrogenic diabetes insipidus (diagnosis), nephrogenic diabetes insipidus, Diabetes insipidus nephrogenic, Nephrogenic diabetes insipidus, NOS, Nephrogenic Diabetes Insipidus, Nephrogen diabetes insip, Diabetes Insipidus, Nephrogenic [Disease/Finding], diabetes insipidus nephrogenic, diabete insipidus nephrogenic, Nephrogenic diabetes insipidus, NDI - Nephrogenic diabetes insipidus, Nephrogenic diabetes insipidus (disorder), diabetes; insipidus, nephrogenic, nephrogenic; diabetes insipidus, Nephrogenic diabetes insipidus -RETIRED-
Spanish DIABETES INSIPIDA NEFROGENICA, Diabetes insípida nefrógena, diabetes insípida nefrógena, diabetes insípida nefrogénica, diabetes insípida nefrogénica - RETIRADO - (concepto no activo), diabetes insípida nefrogénica - RETIRADO -, diabetes insípida nefrógena (trastorno), Diabetes insípida nefrogénica, Diabetes Insípida Nefrogénica
Dutch diabetes insipidus nefrogeen, diabetes; insipidus, nefrogeen, nefrogeen; diabetes insipidus, nefrogene diabetes insipidus, Diabetes insipidus, nefrogene, Nefrogene diabetes insipidus
French Diabète insipide néphrogène, DIABETE INSIPIDE NEPHROGENIGUE, DIN (Diabète Insipide Néphrogénique), Diabète insipide néphrogénique
German Diabetes insipidus nephrogen, DIABETES INSIPIDUS NEPHROGEN, Renaler Diabetes insipidus, nephrogener Diabetes insipidus, Diabetes insipidus, nephrogener
Swedish Diabetes insipidus, nefrogen
Japanese ジンセイニョウホウショウ, 腎形成性尿崩症, 尿崩症-腎性, 腎原発性尿崩症, 腎性尿崩症, 尿崩症-腎原発性
Czech diabetes insipidus nefrogenní, Nefrogenní diabetes insipidus
Finnish Renaalinen diabetes insipidus
Portuguese DIABETES INSIPIDUS NEFROGENICO, Diabetes insípida nefrogénica, Diabetes Insípido Nefrogênico
Korean 콩팥(신장성) 요붕증
Polish Moczówka prosta nerkowa
Hungarian nephrogen diabetes insipidus
Norwegian Nefrogen diabetes insipidus, Diabetes insipidus, nefrogen
Italian Diabete insipido nefrogeno
Derived from the NIH UMLS (Unified Medical Language System)

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