Pharmacology Book

//fpnotebook.com/

Cytochrome P-450 2C19 Isoenzyme

Aka: Cytochrome P-450 2C19 Isoenzyme, CYP2C19, CYP2C19 Inducer, CYP2C19 Inhibitor, CYP2C19 Substrate
  1. See Also
    1. CYP2C9
  2. Precautions: Pharmacogenetics
    1. See Pharmacogenetics
    2. Poor metabolizers (2-15%, 20% in asians)
      1. Clopidogrel with reduced conversion to active form (higher risk for stent closure)
      2. Amitriptyline and Nortriptyline risk of toxicity (reduce starting dose by 50%)
      3. Citalopram, Escitalopram, Sertraline risk of toxicity (reduce starting dose by 50%)
      4. Omeprazole blood concentrations are 5x higher (increased efficacy)
    3. Ultra-Metabolizers (18% of Swedes and 18% of Ethiopians)
      1. Citalopram, Escitalopram, Sertraline with reduced effect (consider alternative agents)
      2. Omeprazole blood concentrations are 40% lower
    4. Reference
      1. Sim (2006) Clin Pharmacol Ther 79:103-13 [PubMed]
  3. Interactions: Metabolized by CYP2C19 (Substrates)
    1. Neuropsychiatric drugs
      1. Clomipramine
      2. Imipramine
      3. Hexobarbital
      4. Mephobarbital
      5. Diazepam
      6. Phenobarbital
      7. Phenytoin
    2. Cardiopulmonary Drugs
      1. Propranolol (Inderal)
    3. Antibiotics
      1. Nelfinavir
    4. Miscellaneous
      1. Lansoprazole
      2. Pentamidine
      3. Felbamate
      4. Omeprazole (Prilosec)
  4. Interactions: Inhibitor of CYP2C19
    1. Neuropsychiatric drugs
      1. Fluvoxamine (Luvox)
    2. Antibiotics
      1. Isoniazid (INH)
      2. Ritonavir
    3. Miscellaneous
      1. Omeprazole (Prilosec)
      2. Cimetidine
  5. Interactions: Inducer of CYP2C19
    1. Neuropsychiatric Drugs
      1. Carbamazepine
      2. Phenytoin
    2. Antibiotics
      1. Rifampin

CYP2C19 protein, human (C0960580)

Definition (NCI) Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH C045793
SnomedCT 423556000
English cytochrome P450 CYP2C(mp), cytochrome P450 2C19, human, Cytochrome p450 CYP2C19 enzyme (substance), Cytochrome p450 CYP2C19 enzyme, CYP2C19, cyp2c19, Mephenytoin 4-Hydroxylase, Cytochrome P450-11A, (S)- Limonene 6-Monooxygenase, EC 1.14.13.48, EC 1.14.13.49, (S)- Limonene 7-Monooxygenase, EC 1.14.13.-, (R)- Limonene 6-Monooxygenase, Cytochrome P450-254C, EC 1.14.13.80, Cytochrome P450 2C19, Cytochrome P450, Family 2, Subfamily C, Polypeptide 19, cytochrome P450 CYP2C19 (human), CYP2C(mp) protein, human, CYP2C19, human, CYPIIC19, human, P4502C19, human, cytochrome p-450 mephenytoin 4-hydroxylase, human, mephenytoin hydroxylase, human, propranolol 4-hydroxylase, human, (S)-mephenytoin-4'-hydroxylase, human, CYP2C19 protein, human, Flavoprotein-Linked Monooxygenase, CYPIIC17, CYPIIC19, P450-11A, P450-254C, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19, Mephenytoin 4'-Hydroxylase, Mephenytoin 4-Prime-Hydroxylase, Microsomal Monooxygenase, Xenobiotic Monooxygenase
Spanish enzima CYP2C19 del citocromo p450, enzima CYP2C19 del citocromo p450 (sustancia), CYP2C19
Sources
Derived from the NIH UMLS (Unified Medical Language System)


You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree