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Nalmefene
Aka: Nalmefene, Revex
- Indications
- Narcotic Toxicity requiring frequent Naloxone dosing
- Precautions
- Do not use as first line agent for Narcotic Toxicity
- Risk of severe Narcotic Withdrawal
- Pharmacokinetics
- Long acting Opioid antagonist
- Duration: 4-8 hours
- Dosing
- Opioid Overdose
- Initial: 0.5 mg per 70 kg person IV
- Later: 1 mg per 70 kg IV prn 5 min after initial dose
- Narcotic dependent: 0.1 mg per 70 kg test dose
- Post-operative Narcotic reversal
- Dose: 0.25 ug/kg IV q2-5 minutes
- Maximum: 1 ug/kg total dose