Pharmacology Book

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Nalmefene

Aka: Nalmefene, Revex
  1. Indications
    1. Narcotic Toxicity requiring frequent Naloxone dosing
  2. Precautions
    1. Do not use as first line agent for Narcotic Toxicity
    2. Risk of severe Narcotic Withdrawal
  3. Pharmacokinetics
    1. Long acting Opioid antagonist
    2. Duration: 4-8 hours
  4. Dosing
    1. Opioid Overdose
      1. Initial: 0.5 mg per 70 kg person IV
      2. Later: 1 mg per 70 kg IV prn 5 min after initial dose
      3. Narcotic dependent: 0.1 mg per 70 kg test dose
    2. Post-operative Narcotic reversal
      1. Dose: 0.25 ug/kg IV q2-5 minutes
      2. Maximum: 1 ug/kg total dose

nalmefene (C0068377)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C038981
SnomedCT 109098006
English 6-desoxy-6-methylenenaltrexone, nalmefene, NALMEFENE, nalmefene [Chemical/Ingredient], Nalmefene (substance), Nalmefene
Spanish nalmefeno (sustancia), nalmefeno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Revex (C0723050)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C038981
English Revex, nalmefene hydrochloride (Revex), revex
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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