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Glucosamine
Aka: Glucosamine, Glucosamine Sulfate
- See Also
- Osteoarthritis
- Chondroitin
- Pathophysiology
- Glucosamine is endogenous amino sugar, a precursor of glycosaminoglycans
- Glycosaminoglycans are present in joint structures such as Synovial Fluid
- Effects
- Stimulates chondrocyte metabolism
- May have anti-inflammatory effects at higher dose
- Source
- Marine exoskeleton or
- Synthetically derived
- Efficacy
- Appears more effective than Placebo at relieving pain
- Effect requires at least one month of therapy
- Less Knee Joint space narrowing with Glucosamine over Placebo in 3 years
- Reginster (2001) Lancet 357:251-6 [PubMed]
- Dosing
- Glucosamine 500 mg orally three times daily
- Adverse Effects
- Gastrointestinal upset
- Hemoglobin A1C and Serum Glucose are NOT impacted (contrary to initial reports)
- Scroggie (2003) Arch Intern Med 163:1587-90
- Glucosamine is safe in shellfish allergy (despite marine exoskeleton source)
- Gray (2004) J Allergy Clin Immunol 114:459-60 [PubMed]
-
Drug Interactions
- Warfarin (Coumadin)
- Warfarin's Anticoagulation effect is increased
- References
- Delafuente (2000) Rheum Dis Clin North Am 26:1-11 [PubMed]
- McAlindon (2000) JAMA 283:1469-75 [PubMed]
- Richy (2003) Arch Intern Med 163:1514-22 [PubMed]