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Topiramate
Aka: Topiramate, Topamax- Indications
- Adverse Effects: Dose related
- Adverse Effects: Other
-
Drug Interactions
- Other Seizure medications
- Dose: Adult
- Initial: 25-50 mg/day (consider start just qhs)
- Increase by 25-50 mg/day increments per week
- Target
- Adults: 400 mg/day divided bid
- Elderly: 200 mg/day divided bid
- Maximum dose: 1600 mg/day divided bid
- Dose: Child
- Initial: 1-3 mg/kg up to 25 mg PO qhs for 1 week
- Increase by 1-3 mg/kg/day to 25 mg increments per week
- Target range: 5-9 mg/kg/day divided bid
- Precautions
- Adjust dose if Creatinine Clearance <60 ml/min/sec
Medication Costs | ||
---|---|---|
topiramate (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
TOPIRAMATE 100 MG TABLET | Generic | $0.08 each |
TOPIRAMATE 15 MG SPRINKLE CAP | Generic | $0.34 each |
TOPIRAMATE 200 MG TABLET | Generic | $0.11 each |
TOPIRAMATE 25 MG SPRINKLE CAP | Generic | $0.42 each |
TOPIRAMATE 25 MG TABLET | Generic | $0.03 each |
TOPIRAMATE 50 MG TABLET | Generic | $0.06 each |
TOPIRAMATE ER 100 MG CAPSULE | Generic | $10.07 each |
TOPIRAMATE ER 150 MG CAPSULE | Generic | $12.80 each |
TOPIRAMATE ER 200 MG CAPSULE | Generic | $14.53 each |
TOPIRAMATE ER 50 MG CAPSULE | Generic | $5.19 each |
topamax (on 3/22/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
TOPAMAX 100 MG TABLET | Generic | $0.08 each |
TOPAMAX 200 MG TABLET | Generic | $0.11 each |
TOPAMAX 25 MG SPRINKLE CAP | Generic | $0.42 each |
TOPAMAX 25 MG TABLET | Generic | $0.03 each |
TOPAMAX 50 MG TABLET | Generic | $0.06 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
topiramate (C0076829) |
|
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Definition (CHV) | a kind of anticonvulsant drug |
Definition (NCI) | A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C052342 |
SnomedCT | 108400009, 386844006 |
LNC | LP19239-0, MTHU007741 |
English | 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate, topiramate, beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate, topiramate (medication), TOPIRAMATE, topiramate [Chemical/Ingredient], Topiramate, Topiramate (product), Topiramate (substance) |
Spanish | topiramato (producto), topiramato (sustancia), topiramato |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Topamax (C0723778) |
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Definition (CHV) | a migraine treatment medication |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C052342 |
English | Topamax, topiramate (Topamax), Cilag brand of topiramate, Epitomax, Janssen brand of topiramate, Ortho brand of topiramate |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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