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Primidone
Aka: Primidone, Mysoline
- Indications
- Seizure Disorder
- Grand Mal Seizure
- Psychomotor Seizure
- Focal Seizure
- Essential Tremor
- Contraindications
- Porphyria
- Phenobarbital Hypersensitivity
- Mechanism
- Barbiturate with 2 active metabolites
- Phenobarbital
- Phenylethylmalonamide (PEMA)
- Raises Seizure threshold
- Dosing: adults and children over age 8 years
- Titration to maintenance dose
- Days 1 to 3: Take 100-125 mg PO qhs
- Days 4 to 6: Take 100-125 mg PO bid
- Days 7 to 9: Take 100-125 mg PO tid
- Days >10: Take 250 mg PO tid
- Maintenance dosing
- Standard dosing: 250 mg PO tid-qid
- Maximum dosing: 500 mg PO qid (do not exceed)
- Monitoring: Labs every 6 months
- Complete Blood Count
- Chemistry panel (SMA-12)
- Adverse effects
- Common
- Ataxia
- Vertigo
- Occasional
- Nausea, Vomiting or Anorexia
- Fatigue or drowsiness
- Hyperirritability or other emotional disturbance
- Sexual Impotence
- Diplopia or Nystagmus
- Morbilliform skin rash
- Rare
- Megaloblastic Anemia responsive to Folate