Neurology Book

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Gepant

Aka: Gepant, Ubrogepant, Ubrelvy
  1. See Also
    1. Calcitonin Gene-Related Peptide Blocker
  2. Indications
    1. Acute Migraine Headache
      1. Third-line agent in acute Migraine Headaches refractory to NSAIDS and Triptans
  3. Mechanism
    1. Blocks CalcitoninGene-Related Peptide (CGRP)
      1. CGRP is a vasodilator and pain sensitizer
  4. Preparations
    1. Ubrogepant (Ubrelvy)
      1. Costs $85 per tablet (contrast with 70 cents per Sumatriptan tablet)
      2. May be repeated 2 hours after first dose if inadequate effect
  5. Efficacy
    1. NNT 10 for one patient to be pain free at 2 hours
      1. Contrast with NNT 5 for Sumatriptan
  6. References
    1. (2020) Presc Lett 27(3): 13

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