Neurology Book

//fpnotebook.com/

Gepant

Aka: Gepant, Ubrogepant, Ubrelvy, Rimegepant, Nurtec
  1. See Also
    1. Calcitonin Gene-Related Peptide Blocker
  2. Indications
    1. Acute Migraine Headache
      1. Third-line agent in acute Migraine Headaches refractory to NSAIDS and Triptans
  3. Mechanism
    1. Blocks CalcitoninGene-Related Peptide (CGRP)
      1. CGRP is a vasodilator and pain sensitizer
  4. Preparations
    1. Ubrogepant (Ubrelvy)
      1. Costs $85 per tablet (contrast with 70 cents per Sumatriptan tablet)
      2. May be repeated 2 hours after first dose if inadequate effect
    2. Rimegepant (Nurtec)
      1. Dissolving oral tablet: 75 mg taken as single dose (maximum 75 mg/day)
  5. Efficacy
    1. NNT 10 for one patient to be pain free at 2 hours
      1. Contrast with NNT 5 for Sumatriptan
  6. Adverse Effects
    1. Nausea
  7. Drug Interactions
    1. CYP3A4 Substrate (Rimegepant)
      1. Drugs levels may be increased by strong CYP3A4 inhibitors
  8. References
    1. (2020) Presc Lett 27(3): 13

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree