Pulmonology Book



Aka: Pyrazinamide
  1. Indications
    1. Active Tuberculosis
  2. Dosing
    1. Adult: 1.5-2.5 grams PO qd
    2. Pediatric: 15-30 mg/kg/day (Max 2g/day)
  3. Adverse Effects
    1. Drug-Induced Hepatitis or Hepatotoxicity
    2. Gastrointestinal upset
    3. Transient Morbiliform Rash
    4. Arthralgias (unrelated to gout)
    5. Hyperuricemia or Acute Gout
  4. Monitoring
    1. Baseline
      1. Liver Function Tests
      2. Serum Creatinine
    2. Periodic testing
      1. Liver Function Tests repeated 1-2 times monthly if risks for hepatotoxicity
      2. Serum Uric Acid if symptoms related to gout
Medication Costs
pyrazinamide (on 11/30/2016 at Medicaid.Gov Pharmacy Drug pricing)
PYRAZINAMIDE 500 MG TABLET Generic $2.59 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Pyrazinamide (C0034239)

Definition (NCI) A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)
Definition (MSH) A pyrazine that is used therapeutically as an antitubercular agent.
Definition (CSP) antibacterial derived from nicotinic acid, used as a tuberculostatic.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011718
SnomedCT 13592004, 387076005
LNC LP15007-5, MTHU001493
English Pyrazinamide, Pyrazinecarboxamide, pyrazinamide, pyrazinamide (medication), Pyrazinamide [Chemical/Ingredient], PYRAZINAMIDE, Pyrazinoic acid amide, Pyrazinamide (product), Pyrazinamide (substance)
Swedish Pyrazinamid
Czech pyrazinamid
Finnish Pyratsiiniamidi
Japanese ピラジナミド
Spanish Pirazinamida, Piracinamida, amida de ácido pirazinoico, pirazinamida (producto), pirazinamida (sustancia), pirazinamida
Polish Pirazynamid
French Pyrazinamide
German Pyrazinamid
Italian Pirazinamide
Portuguese Pirazinamida
Derived from the NIH UMLS (Unified Medical Language System)

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