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Pyrazinamide
Aka: Pyrazinamide- Dosing
- Adult: 1.5-2.5 grams PO qd
- Pediatric: 15-30 mg/kg/day (Max 2g/day)
- Adverse Effects
- Hepatotoxicity
- Arthralgias
- Gastrointestinal upset
- Rash
- Hyperuricemia
- Monitoring
- Baseline
- Periodic testing
- Liver Function Tests repeated 1-2 times monthly if risks for hepatotoxicity
- Serum Uric Acid if symptoms related to gout
| Medication Costs | ||
|---|---|---|
| pyrazinamide (on 11/30/2016 at Medicaid.Gov Pharmacy Drug pricing) | ||
| PYRAZINAMIDE 500 MG TABLET | Generic | $2.59 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Pyrazinamide (C0034239) |
|
|---|---|
| Definition (NCI) | A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04) |
| Definition (MSH) | A pyrazine that is used therapeutically as an antitubercular agent. |
| Definition (CSP) | antibacterial derived from nicotinic acid, used as a tuberculostatic. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D011718 |
| SnomedCT | 13592004, 387076005 |
| LNC | LP15007-5, MTHU001493 |
| English | Pyrazinamide, Pyrazinecarboxamide, pyrazinamide, pyrazinamide (medication), Pyrazinamide [Chemical/Ingredient], PYRAZINAMIDE, Pyrazinoic acid amide, Pyrazinamide (product), Pyrazinamide (substance) |
| Swedish | Pyrazinamid |
| Czech | pyrazinamid |
| Finnish | Pyratsiiniamidi |
| Russian | PIRAZINAMID, ПИРАЗИНАМИД |
| Japanese | ピラジナミド |
| Spanish | Pirazinamida, Piracinamida, amida de ácido pirazinoico, pirazinamida (producto), pirazinamida (sustancia), pirazinamida |
| Polish | Pirazynamid |
| French | Pyrazinamide |
| German | Pyrazinamid |
| Italian | Pirazinamide |
| Portuguese | Pirazinamida |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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