Pulmonology Book

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Cough Expectorant

Aka: Cough Expectorant, Protussive, Guaifenesin, Robitussin, Humibid, Liquibid, Guaifenex
  1. See Also
    1. Cough Suppressant
    2. Cough Symptomatic Treatment
  2. Indications
    1. Infectious cough (may speed recovery)
    2. Chronic Bronchitis (clear airway mucus)
    3. Acute Sinusitis (assists with sinus drainage)
  3. Guaifenesin
    1. Short acting agents (e.g. Robitussin)
      1. Ages 2 to 5 years old: 2.5 ml PO q4h
      2. Ages 6 to 12 years old: 5 ml PO q4h
      3. Adults: 10 ml PO q4h
    2. Long acting agents
      1. Mucinex (Over-the-counter)
      2. Humabid LA with new, unproven formulation
        1. Contains guiacolsulfonate (old expectorant)
    3. Discontinued agents
      1. Prior Humibid LA, Liquibid, Guaifenex LA
    4. Effect
      1. The only effective expectorant medication per FDA
      2. Paradoxically also reduces cough in URI
        1. Due to altered cough receptor sensitivity in URI
        2. Dicpinigaitis (2003) Chest 124:2178-81 [PubMed]
  4. Other Expectorant Preparations (use with caution)
    1. Nebulized Hypertonic Saline
      1. Used to induce Sputum for Sputum exam and culture
    2. Terbutaline (Brethine)
      1. Beta adrenergic agonist (Tachycardia risk)
      2. Dose (age >12): 2.5 to 5 mg PO q6 hours while awake
    3. Amiloride (Midamor)
      1. Potassium sparing Diuretic
Medication Costs
guaifenesin (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
GUAIFENESIN 100 MG/5 ML LIQUID Generic OTC $0.01 per ml
GUAIFENESIN 100 MG/5 ML SYRUP Generic OTC $0.01 per ml
GUAIFENESIN 200 MG TABLET Generic OTC $0.04 each
GUAIFENESIN AC COUGH SYRUP Generic OTC $0.03 per ml
GUAIFENESIN DM SYRUP Generic OTC $0.01 per ml
GUAIFENESIN ER 1,200 MG TABLET Generic OTC $0.53 each
GUAIFENESIN ER 600 MG TABLET Generic OTC $0.26 each
GUAIFENESIN-CODEINE SYRUP Generic OTC $0.03 per ml
GUAIFENESIN-PSE ER 600-60 MG Generic OTC $0.40 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Guaifenesin (C0018305)

Definition (CHV) An expectorant
Definition (CHV) An expectorant
Definition (CHV) An expectorant
Definition (CHV) An expectorant
Definition (NCI) A glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway.
Definition (MSH) An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006140
SnomedCT 363737009, 87174009, 386184000
LNC LP18968-5, MTHU007063
English Ether, Guaiacol Glyceryl, Glycerol Guaiacolate, Glyceryl Ether, Guaiacol, Guaiacolate, Glycerol, Guaifenesin, Guaiphenesin, Guaiphenezine, 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 3-(o-Methoxyphenoxy)-1,2-propanediol, Glyceryl Guaiacolate, guaifenesin (medication), GUAIFENESIN, Guaifenesin [Chemical/Ingredient], guaiacol glyceryl ether, guaiphenesin, glyceryl guaiacolate, guaifenesin, guaiFENesin, GuaiFENesin, Guaifenesin - chemical, Guaifenesin - chemical (substance), Guaiacol Glyceryl Ether, Glyceryl guaiacolate, Guaianesin, alpha-Glyceryl guaiacol ether, Guaifenesin (product), Guaifenesin (substance)
Swedish Guaifenesin
Czech guaifenesin, guajakol glycerylether
Finnish Guaifenesiini
Russian GVAIFENEZIN, GVAIAKOLGLITSERINOVYI EFIR, ГВАЙФЕНЕЗИН, ГВАЯКОЛГЛИЦЕРИНОВЫЙ ЭФИР
Japanese グアイフェネシン, グアヤコールグリセリンエーテル, グアイアコールグリセリルエーテル, フストジル
Polish Eter glicerynowy gwajakolu, Guaifenezyna
Spanish guaifenesina - sustancia química (sustancia), guaifenesina - sustancia química, gliceril guayacolato, guaifenesina (producto), guaifenesina (sustancia), guaifenesina, guayanesina, éter de alfagliceril guayacolato, Guaifenesina, Éter Guayacol Glicerilo
French Éther glycérique du gaïacol, Éther glycérogaïacolique, Éther monoglycérique du gaïacol, Gaïacolate de glycérol, Gaïacolate de glycéryle, Glycéryl gaïacolate, Glycérylgaïacol, Glycéryl guaïacolate, Guaïanésine, Guaïfénésine, Guaïphénésine
German Guaifenesin, Guaiphenesin, Guajakolglycerinether
Italian Guaifenesina
Portuguese Éter Glicerílico do Guaiacol, Guaifenesina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Guaifenex (C0720747)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Guaifenex, guaifenex
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Liquibid (C0721382)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Liquibid, liquibid
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Robitussin (C0723110)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Robitussin, robitussin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Humibid (C0729017)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006140
English humibid, Humibid
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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