Infectious Disease Book


Non-Gonococcal Urethritis

Aka: Non-Gonococcal Urethritis, Nongonococcal Urethritis
  1. See Also
    1. Sexually Transmitted Infection
    2. Chlamydia
    3. Gonorrhea
    4. Dysuria
    5. Dysuria in Women
    6. Dysuria in Men
    7. Dysuria in Children
  2. Causes
    1. See Dysuria (Urethritis)
    2. Chlamydia trachomatis (35-45%)
    3. Mycoplasma Genitalium (30%)
    4. Trichomonas vaginalis (13%)
    5. Ureaplasma urealyticum or Ureaplasma parvum
      1. Unclear if Ureaplasma causes Urethritis
    6. Herpes Simplex Virus
  3. Symptoms
    1. Urethral discharge
    2. Dysuria
  4. Differential Diagnosis
    1. See Dysuria
    2. Trichomonas
      1. Consider if no response to Azithromycin, Doxycycline
    3. Chlamydia trachomatis
  5. Labs
    1. See Sexually Transmitted Infection
    2. Gonorrhea PCR
    3. Chlamydia PCR
    4. Trichomonas PCR or Wet Prep
    5. Mycoplasma GenitaliumNAAT may be available (esp for persistent or recurrent symptoms)
  6. Management
    1. Precaution
      1. See Dysuria for a more complete protocol for evaluation and management
      2. Also give Ceftriaxone 500 mg IM/IV for 1 dose (1 gram IM/IV if weight > 150 kg) if Gonorrhea not excluded
    2. First-Line (empiric for Chlamydia AND Trichomonas)
      1. Azithromycin 1 gram for one dose AND
      2. Metronidazole 2 grams for one dose
    3. Alternative regimen
      1. Doxycycline 100 mg orally twice daily for 7 days AND
      2. Tinidazole 2 grams for one dose
    4. Persistent Urethritis
      1. See Dysuria
      2. Consider resistant Mycoplasma Genitalium
        1. See Mycoplasma Genitalium for treatment regimen
        2. Consider Moxifloxacin 400 mg orally daily for 10 days
  7. Resources
    1. Non-Gonococcal Urethritis (Stat Pearls)
  8. References
    1. (2018) Sanford Guide, accessed on IOS 11/7/2019
    2. Stamm (1995) JAMA 274:545-9 [PubMed]
    3. Workowski (2015) MMWR Morb Mortal Wkly Rep 64:1-137 [PubMed]

non-gonococcal urethritis (NGU) (C1112709)

Concepts Disease or Syndrome (T047)
ICD10 N34.1
SnomedCT 84619001
English NGU - Non-GC urethritis, NSGI - Nonspec genit infectn, NGU (nongonococcal urethritis), nongonococcal urethritis, nongonococcal urethritis (diagnosis), Non-gonococcal urethritis, Unspecified nongonococcal urethritis (NGU), Unspecified non-gonococcal urethritis (NGU), NGU - Non-gonococcal urethritis, Nonspecific urethritis, Nonspecific genital infection, NSGI - Nonspecific genital infection, Urethritis-non-specific, NSU - Nonspecific urethritis, NGU, Nongonococcal urethritis, Nongonococcal urethritis (disorder), urethritis; nongonococcal, NGU, NOS, Nongonococcal urethritis, NOS, Nonspecific urethritis, NOS, Non-Gonococcal Urethritis, non-gonococcal urethritis (NGU)
Dutch niet-gonokokkenuretritis, niet-gespecificeerde non-gonokokkenurethritis (NGU), non-gonokokkenurethritis, niet-gespecificeerde niet-gonokokkenuretritis (NGU), urethritis; niet door gonokokken, Niet-specifieke urethritis
French UNG (urétrite non gonococcique), Urétrite non gonococcique, Urétrite non gonococcique non précisée
German NGU, unspezifische nicht von Gonokokken verursachte Urethritis (NGU), nicht von Gonokokken verursachte Urethritis, Unspezifische Urethritis
Italian Uretrite non gonococcica, Uretrite non gonococcica non specificata
Portuguese Uretrite não gonocócica NE, Uretrite não gonocócica
Spanish Uretritis no-gonocócica indeterminada, Uretritis no gonocócica, Uretritis no gonocócica no especificada (UNG), UNG, uretritis no específica, uretritis no gonocócica (trastorno), uretritis no gonocócica
Japanese 詳細不明の非淋菌性尿道炎, 非淋菌性尿道炎, ショウサイフメイノヒリンキンセイニョウドウエン, ヒリンキンセイニョウドウエン
Czech Negonokoková uretritis, Negonokoková uretritida, Blíže neurčená negonokoková uretritida, Blíže neurčená negonokoková uretritis
Korean 비특이성 요도염
Hungarian Nem-gonococcalis urethritis, Non-gonococcalis nem meghatározott urethritis (NGU), Non-gonococcalis urethritis, Nem-gonococcalis nem meghatározott urethritis (NGU), NGU
Derived from the NIH UMLS (Unified Medical Language System)

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