Infectious Disease Book

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Serotype B Meningococcal Vaccine

Aka: Serotype B Meningococcal Vaccine, Trumenba, Bexsero
  1. See Also
    1. Meningococcal Vaccine (Menactra, Menveo, MCV4)
    2. Menomune (MPSV4)
    3. Neisseria Meningitidis
    4. Bacterial Meningitis
  2. Indications (age 10 years old or older)
    1. Serotype B Meningococcal Meningitis exposure
    2. Asplenia
    3. Sickle Cell Disease
    4. Specific immune deficiency
  3. Mechanism
    1. Covers only Serotype B Meningococcus
      1. Accounts for one third of meningococcal cases
      2. Serotype B outbreaks are most common in infants and college students
    2. Contrast with Menactra, Menveo and Menomune which cover serotypes A, C, W and Y
      1. Indicated for all U.S. children as part of the Primary Series
  4. Preparations (FDA approved in 2014)
    1. Must use same preparation for both doses
    2. MenB-FHbp (Trumenba)
      1. Three dose series (0, 2 and 6 months)
      2. Two dose regimen (0 and 6 months)
        1. Two dose regimen may be used for healthy patients ages 16-23 years AND
        2. Not at increased meningococcal disease
    3. MenB-4C (Bexsero)
      1. Two dose series (0 and 1-6 months)
  5. References
    1. Jacobson (2017) Vaccine Update,Mayo Clinic Reviews, Rochester, MN
    2. (2015) Presc Lett 22(10): 59
    3. Ackerman (2015) Am Fam Physician 92(6): 460-8 [PubMed]
    4. Cohn (2013) MMWR Recomm Rep 62(RR-2):1-28 [PubMed]

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