Infectious Disease Book


Serotype B Meningococcal Vaccine

Aka: Serotype B Meningococcal Vaccine, Meningococcal Serogroup B, Trumenba, MenB-FHbp, Bexsero, MenB-4C
  1. See Also
    1. Meningococcal Vaccine (Menactra, Menveo, MCV4)
    2. Menomune (MPSV4)
    3. Neisseria Meningitidis
    4. Bacterial Meningitis
  2. Indications (age 10 years old or older)
    1. Serotype B Meningococcal Meningitis exposure
    2. Asplenia
    3. Sickle Cell Disease
    4. Specific immune deficiency
  3. Mechanism
    1. Covers only Serotype B Meningococcus
      1. Accounts for one third of meningococcal cases
      2. Serotype B outbreaks are most common in infants and college students
    2. Contrast with Menactra, Menveo and Menomune which cover serotypes A, C, W and Y
      1. Indicated for all U.S. children as part of the Primary Series
  4. Preparations (FDA approved in 2014)
    1. Must use same preparation for both doses (not interchangeable)
    2. MenB-FHbp (Trumenba)
      1. Two dose regimen at least 6 months apart (0 and 6 months)
        1. Two dose regimen may be used for healthy patients ages 16-23 years AND
        2. Not at increased meningococcal disease
      2. Three dose series (0, 2 and 6 months)
        1. Indicated for Asplenia, complement deficiency, or complement inhibitor
    3. MenB-4C (Bexsero)
      1. Two dose series at least 1 month apart (0 and 1-6 months)
  5. Resources
    1. CDC Immunization Schedules (last accessed 10/28/2020)
  6. References
    1. Jacobson (2017) Vaccine Update,Mayo Clinic Reviews, Rochester, MN
    2. (2015) Presc Lett 22(10): 59
    3. Ackerman (2015) Am Fam Physician 92(6): 460-8 [PubMed]
    4. Cohn (2013) MMWR Recomm Rep 62(RR-2):1-28 [PubMed]

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