Hematology and Oncology Book

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N-Nitrosodimethylamine

Aka: N-Nitrosodimethylamine, NMDA, Dimethylnitrosamine, N-nitrosodiethylamine, NDEA
  1. Background
    1. NMDA, NDEA are associated with several product recalls
      1. Angiotensin Receptor Blockers or ARBs (e.g. Valasartan) in 2018
        1. https://www.fda.gov/Drugs/DrugSafety/ucm613916.htm
        2. https://www.fda.gov/Safety/Recalls/ucm624593.htm
        3. https://www.fda.gov/Safety/Recalls/ucm625492.htm
      2. OTC Ranitidine in 2019
        1. https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-zantac-ranitidine
  2. Adverse Effects: Carcinogenic Effects
    1. Unclear risk
    2. Low levels of NMDA are present in water, grilled meats, bacon, dairy products
    3. Overall risk appears to be low
      1. With Valsartan, cancer risk was thought to be 1 in 8000 patients taking it for 4-8 years at 320 mg/day
  3. Resources
    1. N-Nitrosodimethylamine (Wikipedia)
      1. https://en.wikipedia.org/wiki/N-Nitrosodimethylamine
  4. References
    1. (2018) Presc Lett 25(9): 49
    2. (2018) Presc Lett 26(11): 62

Dimethylnitrosamine (C0012431)

Definition (NCI) A volatile, combustible, yellow, oily liquid nitrosamine with a faint characteristic odor that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosodimethylamine is primarily used in laboratory research to induce tumors in experimental animals. This substance may be formed during the cooking of foods, especially cured meats and fish, that contain sodium nitrite as a preservative, but is also found in several vegetables, cheeses, alcoholic beverages and fruits, and as a contaminant in rubber products. Exposure to NNitrosodimethylamine irritates the skin and eyes and damages the liver. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
Definition (MSH) A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.
Concepts Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D004128
LNC LP34821-6, MTHU017307
English Nitrosodimethylamine, Methanamine, N-methyl-N-nitroso-, NDMA, DMN, DMNA, N-Methyl-N-nitrosomethanamine, Dimethylnitrosamine, N-Nitrosodimethylamine, Nitrosodimethylamine, NDMA, NDMA Nitrosodimethylamine, N Nitrosodimethylamine, dimethylnitrosamine, Dimethylnitrosamine [Chemical/Ingredient], N nitrosodimethylamine, nitrosodimethylamine, N-nitrosodimethylamine, N-NITROSODIMETHYLAMINE
Swedish Dimetylnitrosamin
Czech dimethylnitrosamin
Finnish Dimetyylinitrosamiini
Russian NITROZODIMETILAMIN, DIMETILNITROZAMIN, ДИМЕТИЛНИТРОЗАМИН, НИТРОЗОДИМЕТИЛАМИН
Polish Dimetylonitrozoamina, Dwumetylonitrozoamina
Japanese ジメチルニトロサミン, ジメチルニトロソアミン, ニトロソジメチルアミン
French Diméthyl-nitrosamine, Diméthylnitrosamine, N-Méthyl-N-nitroso-méthanamine, N-Méthyl-N-nitrosométhanamine
German Dimethylnitrosamin, Nitrosodimethylamin
Italian Dimetilnitrosoamina
Portuguese Dimetilnitrosamina, Nitrosodimetilamina
Spanish Dimetilnitrosamina, Nitrosodimetilamina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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