Hematology and Oncology Book


Transfusion Complication

Aka: Transfusion Complication, Transfusion Reaction, Immune Transfusion Reaction
  1. See Also
    1. Blood Transfusion
    2. Platelet Transfusion
    3. Cryoprecipitate
    4. Plasma Transfusion
    5. Transfusion Hemolysis
    6. Transfusion-Related Acute Lung Injury (TRALI)
    7. Transfusion Associated Circulatory Overload (TACO)
    8. Febrile Nonhemolytic Transfusion Reaction (FNHTR)
    9. Allergic Transfusion Reaction
    10. Transfusion Associated Graft Versus Host Disease (TAGVHD)
  2. Complications: Acute (within minutes to 24 hours)
    1. See Transfusion-Related Acute Lung Injury (TRALI)
    2. See Transfusion Associated Circulatory Overload (TACO)
    3. See Febrile Nonhemolytic Transfusion Reaction (FNHTR)
    4. See Allergic Transfusion Reaction
    5. Immune reaction (observe patient closely for the first 15 minutes of transfusion)
      1. Transfusion Hemolysis
      2. Allergic Transfusion Reaction
        1. Reaction to Antigens in donor's blood, not the Blood Type itself
      3. Anaphylaxis to Transfusion
        1. Associated with IgA deficient patients exposed to IgA in donor blood
      4. Urticaria
    6. Complication of Massive Transfusion
      1. Hyperkalemia
      2. Ammonia toxicity
      3. Citrate toxicity
      4. Dilutional Coagulopathy
      5. Thrombocytopenia
    7. Secondary Sepsis from Bacterial contamination of Blood Product
      1. Incidence: 1 per 100,000 transfusions overall (up to 1 in 3000 for Platelet Transfusion)
      2. Most common organisms are normal skin flora (Staphylococcus and Streptococcus)
      3. Onset within first 24 hours of transfusion
      4. Initiate early aggressive management on recognition of Sepsis
        1. Broad spectrum antibiotics including Gram Positive, Gram Negative and Pseudomonas coverage
    8. Intravenous Access Complication
      1. Air Embolism
      2. Thrombophlebitis
  3. Complications: Delayed
    1. See Transfusion Associated Graft Versus Host Disease (TAGVHD)
    2. Delayed Transfusion Hemolysis (Extravascular Hemolysis due to minor incompatibility)
    3. Iron Overload (Hemochromatosis)
    4. Post-transfusion Purpura
  4. Causes: Infection
    1. Hepatitis BVirus Infection (1 in 350,000)
    2. Hepatitis CVirus Infection (1 in 1.8 Million)
    3. Human T-Lymphotrophic Virus 1 or 2 (1 in 2 Million)
    4. Human Immunodeficiency Virus (1 in 2.3 Million)
    5. Malaria (rare)
    6. Babesiosis (rare)
    7. Pandemic Influenza (rare)
    8. Human Herpes Virus 8 (rare)
    9. West Nile Virus (rare)
    10. Creutzfeldt-Jakob Disease (rare)
    11. Syphilis
    12. Cytomegalovirus (CMV)
    13. Toxoplasmosis
    14. Brucellosis
  5. References
    1. Hendrickson (2009) Anesth Analg 108(3): 759-69 [PubMed]
    2. Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
    3. Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]

Transfusion Reaction (C0274435)

Definition (MSH) Complications of BLOOD TRANSFUSION.
Definition (NOC) Severity of complications with blood transfusion reaction
Concepts Pathologic Function (T046)
MSH D001787, D065227
ICD9 999.80
ICD10 T80.92
SnomedCT 270554002, 157797009, 213330007, 82545002
LNC LP18652-5, MTHU005052, LA7476-0
Italian Reazione da trasfusione
Japanese 輸血反応, ユケツハンノウ
English Blood Transfusion Reaction, complication of blood transfusion (diagnosis), complication of blood transfusion, blood transfusion reaction, blood transfusion reaction (diagnosis), blood transfusion complications, Transfusion reaction, unspecified, Adverse effect;transfusion, blood transfusion reactions, reactions transfusion, blood complications transfusion, blood complications transfusions, blood reaction transfusion, blood transfusion complication, transfusion reaction, blood complication transfusion, transfusion reactions, blood reactions transfusion, Transfusion reaction NOS, Unspecified transfusion reaction, Transfusion reaction NOS (disorder), Transfusion Reactions, Transfusion Reaction, Transfusion reaction, Complication of blood transfusion, Blood transfusion reaction (disorder), Blood transfusion reaction, complications; transfusion, reaction, transfusion; complications, reaction, Blood transfusion reaction, NOS, Complication of blood transfusion, NOS, Transfusion reaction, NOS
Czech Transfuzní reakce
Hungarian Transzfúziós reakció
Spanish reacción transfusional, SAI (trastorno), reacción transfusional, SAI, complicación de la transfusión de sangre, reacción a la transfusión de sangre (trastorno), reacción a la transfusión de sangre, reacción a una transfusión, Reacción transfusional
Norwegian Transfusjonsreaksjon
Dutch complicaties; transfusie, reactie, transfusie; complicaties, reactie, transfusiereactie
Portuguese Reacção transfusional
French Réaction post-transfusionnelle
German Transfusionsreaktion
Derived from the NIH UMLS (Unified Medical Language System)

Transfusion related complication (C1112143)

Concepts Pathologic Function (T046)
Italian Complicazioni correlate a trasfusione, Complicazione correlata a trasfusione
Czech Komplikace spojené s podáním krevních derivátů, Komplikace související s transfuzí
English Transfusion related complication, Transfusion related complications, complications; transfusion, transfusion; complications
Spanish Complicación relacionada con transfusión, Complicaciones de la transfusión sanguínea
Portuguese Complicação relacionada com transfusão, Complicações associadas a transfusões
German Komplikation in Verbindung mit Transfusion, Transfusionsbedingte Komplikationen
French Complication liée à la perfusion, Complications de la transfusion
Dutch transfusiegerelateerde complicatie, complicaties; transfusie, transfusie; complicaties, transfusiegerelateerde complicaties
Hungarian Transzfúzióval kapcsolatos komplikációk, Transzfúzióval összefüggő komplikáció
Japanese ユケツカンレンガッペイショウ, 輸血関連合併症
Derived from the NIH UMLS (Unified Medical Language System)

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