Hematology and Oncology Book


Osteomyelitis in Sickle Cell Anemia

Aka: Osteomyelitis in Sickle Cell Anemia
  1. See Also
    1. Osteomyelitis
  2. Pathophysiology
    1. Infection of infarcted bone, especially long bones (multiple sites in same bone may be involved)
  3. Causes
    1. Salmonella
      1. Most common organism in Sickle Cell AnemiaOsteomyelitis
    2. Staphylococcal Aureus (<25% of cases)
  4. Signs
    1. Fever
      1. Fever duration directly correlates with likelihood of Osteomyelitis (risk increases 80% each day of fever)
    2. Extremity swelling
      1. Osteomyelitis likelihood increases 8.4 fold
    3. Bone pain
      1. Osteomyelitis likelihood increases 20% each day of pain
  5. Diagnosis
    1. Bone Culture
  6. Labs
    1. Blood Cultures
      1. Test Sensitivity: 30 to 76%
  7. Imaging
    1. See Osteomyelitis
    2. Interpretation may be difficult in Sickle Cell Anemia as bone infarcts may appear similar to Osteomyelitis
  8. Management
    1. Welsh and Welsh (2016) Crit Dec Emerg Med 30(11): 15-23

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