//fpnotebook.com/
Extrinsic Clotting Pathway
Aka: Extrinsic Clotting Pathway
- See Also
- Clotting Pathway
- Intrinsic Clotting Pathway
- Common Clotting Pathway
- Bleeding Disorder
- Prothrombin Time
- Partial Thromboplastin Time
- Thrombin Time
- Pathophysiology
- Initiated by disrupted cell membranes
- Images
- Overview

- Physiology: Extrinsic Clotting Pathway
- Initiated by disrupted cell membranes
- Damaged cells (including vascular endothelial cells) release Tissue Thromboplastin
- Pathway is relatively rapid with Blood Clotting occuring within 15 seconds
- Factor VII, Factor V and Calcium combine to trigger conversion of Factor X to Xa
- Factor Xa then proceeds into the Common Clotting Pathway, generating Thrombin and then Fibrin
- Labs: Prolonged Times in Extrinsic Clotting Pathway Disorders
- Prothrombin Time