Hematology and Oncology Book

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Purpura Causes

Aka: Purpura Causes
  1. See Also
    1. Purpura
    2. Bleeding Disorder
    3. Thrombocytopenia
  2. Causes: Platelet Disorders
    1. See Thrombocytopenia Causes (Most common)
    2. See Platelet Dysfunction
  3. Causes: Coagulation Factor Deficiency
    1. Congenital
      1. Factor VIII Deficiency
      2. Factor IX Deficiency
      3. Von Willebrand's Disease
    2. Acquired
      1. Disseminated Intravascular Coagulopathy
      2. Liver disease
      3. Vitamin K Deficiency
      4. Uremia
  4. Causes: Vascular Factors
    1. Congenital
      1. Hereditary Hemorrhagic Telangiectasia
        1. Autosomal Dominant
        2. Fragile telangiectasias of skin and mucus membranes
      2. Ehlers-Danlos Syndrome (Type IV)
        1. Skin hyperelasticity
        2. Joint Hypermobility
        3. Fragile skin and blood vessels
    2. Acquired: Infections
      1. Henoch-Schonlein Purpura (HSP)
      2. Meningococcemia
      3. Rickettsial Disease
      4. Measles
      5. Scarlet Fever
      6. Typhoid
    3. Acquired: Medications
      1. Atropine
      2. Chloral Hydrate
      3. Long-term Corticosteroids
      4. Iodides
      5. Arsenicals
    4. Acquired: Trauma
      1. Violent coughing, Vomiting or Strangulation
        1. Petechiae in the head and neck (above the nipple line)
      2. Factitious Purpura (linear Petechiae)
      3. Religious rituals (e.g. Cupping or coining)
      4. Child Abuse (Nonaccidental Trauma)
      5. Psychogenic Purpura (Gardner-Diamond Syndrome)
    5. Acquired: Other
      1. Vitamin C Deficiency (Scurvy)
  5. References
    1. Baselga (1997) J Am Acad Dermatol 37:673-705 [PubMed]
    2. Leung (2001) Am Fam Physician 64(3): 419-28 [PubMed]
    3. Stevens (1995) Am Fam Physician 52(5):1355-62 [PubMed]

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