Human Immunodeficiency Virus Book


Non-Nucleoside Reverse Transcriptase Inhibitor

Aka: Non-Nucleoside Reverse Transcriptase Inhibitor, NNRTI, Rilpivirine, Endurant, Delavirdine, Rescriptor
  1. See Also
    1. Anti-Retroviral Therapy
  2. Mechanism
    1. Bind directly to reverse transcriptase
    2. Prevents RNA conversion to DNA
    3. Completely different mechanism than nRTI
  3. Preparations: First Generation
    1. Delavirdine (Rescriptor)
    2. Efavirenz (Sustiva, EFV)
    3. Nevirapine (Viramune, NVP)
  4. Preparations: Second Generation
    1. Etravirine (Intelence)
      1. Approved in treatment experienced patients
    2. Rilpivirine (Endurant)
      1. FDA approved in 2011 for treatment-naive patients
      2. Available as oral agent and monthly IM Injection (as part of Cabenuva therapy)
  5. Adverse Reaction
    1. See specific agents
    2. Hyperlipidemia
    3. Rash is common (especially with Nevirapine)
      1. More common and more severe in women
      2. Reduced Incidence if start dose slowly over 2 weeks
      3. Prophylaxis not recommended (e.g. Corticosteroids)
        1. Antinori (2001) AIDS 15:1579-81 [PubMed]
      4. Switching to a different drug class may be needed
      5. My progress to Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Erythema Multiforme
        1. Severe rash is especially more common with Etravirine and especially in women
  6. References
    1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]

Non-Nucleoside Reverse Transcriptase Inhibitors [MoA] (C1373120)

Concepts Molecular Function (T044)
English Non-Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors [MoA]
Derived from the NIH UMLS (Unified Medical Language System)

You are currently viewing the original '\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree