Human Immunodeficiency Virus Book


Entry Inhibitor

Aka: Entry Inhibitor, Maraviroc, Selzentry
  1. See Also
    1. Anti-Retroviral Therapy
  2. Class
    1. Anti-retroviral agent
    2. Entry Inhibitor
  3. Mechanism
    1. Blocks HIV to Chemokine (CCR5 - R5) receptor binding on CD4+ Cells
    2. Since only effective on R5 cells - requires R5 tropism test prior to initiating Maraviroc
  4. Indications
    1. Anti-retroviral naive patients
    2. Anti-retroviral experienced patients
  5. Adverse Effects
    1. Well tolerated overall
    2. Fever
    3. Upper respiratory symptoms (e.g. cough, Bronchitis)
    4. Abdominal Pain
    5. Rash
    6. Orthostatic Hypotension
    7. Myalgia
    8. Hepatotoxicity (may be associated with rash and Eosinophilia)
    9. Increased Myocardial Infarction risk
  6. Monitoring
    1. Requires R5 tropism test prior to initiating Maraviroc
  7. References
    1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
    2. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]
Medication Costs
selzentry (on 1/30/2017 at Medicaid.Gov Pharmacy Drug pricing)
SELZENTRY 150 MG TABLET $22.41 each
SELZENTRY 300 MG TABLET $22.45 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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