Human Immunodeficiency Virus Book


  • HIV Related Neuropathy


HIV Related Neuropathy

Aka: HIV Related Neuropathy, Neuropathy in HIV, HIV Peripheral Neuropathy, HIV Associated Polyneuropathy
  1. See Also
    1. Neurologic Manifestations of HIV
    2. Peripheral Neuropathy
  2. Types
    1. Distal Sensory Polyneuropathy (most-common HIV-associated Neuropathy)
      1. Common complication at any stage of HIV Infection
      2. Varicella Zoster Virus (VZV) commonly involved
      3. Toxic Peripheral Neuropathy
        1. HIV Treatment with nRTI agents, especially older agents (e.g. DDI or Didanosine)
    2. Demyelinating Neuropathy
      1. Resembles Guillain-Barre
      2. Seen in early HIV
    3. Ascending sensorimotor Neuropathy with Incontinence or polyradiculopathy
      1. Cytomegalovirus (CMV) infection
        1. May involve the spinal cord segment
        2. May present with a painful extremity
  3. Symptoms: Distal Sensory Polyneuropathy
    1. Distal lower extremity numbness, Paresthesias, or pain
  4. Signs: Distal Sensory Polyneuropathy
    1. Decreased ankle Deep Tendon Reflexes
    2. Decreased lower extremity Sensation (esp. sharp and vibratory Sensation)
  5. Differential Diagnosis
    1. See Peripheral Neuropathy
  6. Management
    1. See Peripheral Neuropathy
    2. General measures
      1. Eliminate Neurotoxins (e.g. older Antiretroviral agents)
      2. Control comorbidities (e.g. Diabetes Mellitus, Alcohol Abuse)
      3. Reduce HIV Viral Load
    3. Symptomatic management
      1. Gabapentin (Neurontin)
      2. Tricyclic Antidepressants
  7. References
    1. Chu (2017) Am Fam Physician 96(3): 161-9 [PubMed]

HIV peripheral neuropathy (C1697744)

Concepts Disease or Syndrome (T047)
Dutch perifere neuropathie ten gevolge van HIV
French Neuropathie périphérique liée au VIH
German periphere Neuropathie bei HIV
Italian Neuropatia periferica HIV-correlata
Portuguese Neuropatia periférica ligada ao HIV
Spanish Neuropatía periférica por VIH
Japanese HIV末梢性ニューロパチー, HIVマッショウセイニューロパチー
Czech Periferní neuropatie HIV
Hungarian HIV peripheriás neuropathia
English HIV peripheral neuropathy
Derived from the NIH UMLS (Unified Medical Language System)

HIV associated polyneuropathy (C3160946)

Concepts Disease or Syndrome (T047)
English HIV associated polyneuropathy
Spanish Polineuropatía asociada al VIH
Portuguese Polineuropatia associada ao HIV
Italian Polineuropatia associata a HIV
German HIV-assoziierte Polyneuropathie
French Polyneuropathie associée au VIH
Dutch hiv-geassocieerde polyneuropathie
Czech Polyneuropatie související s HIV
Japanese HIV関連多発ニューロパチー, HIVカンレンタハツニューロパチー
Hungarian HIV-el összefüggő polyneuropathia
Derived from the NIH UMLS (Unified Medical Language System)

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