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Amitiza
Aka: Amitiza, Lubiprostone- See Also
- Dosing
- Irritable Bowel Syndrome with Constipation: 8 mcg orally twice daily
- Chronic Constipation: 24 mcg orally twice daily
- Adverse Effects
- Nausea (with 24 mcg dose)
- Diarrhea (with 24 mcg dose)
- Chest Pain or Dyspnea
- Follows dose within 1 hour
- Resolves within 3 hours
- Disadvantages
- Low efficacy in Irritable Bowel Syndrome with Constipation: Only 14% respond
- Expensive: $200 per month
- Mechanism
- ClC(2) chloride channel opener
- References