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Benign Premature Thelarche
Aka: Benign Premature Thelarche, Premature Thelarche
- See Also
- Precocious Puberty
- Precocious Puberty Causes
- Benign Premature Adrenarche
- Sexual Development
- Male Tanner Stage
- Female Tanner Stage
- Epidemiology
- Onset as early as age 18 months
- Pathophysiology
- Benign self-limited cause of Precocious Puberty
- Exam
- Examine with girl lying down
- Identify if Breast glandular tissue beneath areola
- Signs
- Early Breast development (not to mature Breast contour)
- Isolated glandular Breast tissue on palpation
- No other signs of Puberty
- Normal prepubertal growth rate
- Differential Diagnosis
- Lipomastia
- Fatty Breast tissue in obese girls
- Imaging
- Bone Age consistent Chronological age
- Ovarian Ultrasound normal
- Labs
- Serum Gonadotropin levels normal
- Serum Estradiol normal
- Management
- Reassurance
- Do not biopsy Breast
- Biopsy results in partial Mastectomy
- Further Breast development abnormal post-biopsy
- Course
- Spontaneous resolution
- References
- Klein (2017) Am Fam Physician 96(9): 590-99 [PubMed]