Endocrinology Book



Aka: Plenity, Cellulose and Citric Acid
  1. See Also
    1. Obesity Management
  2. Indications
    1. Obesity (BMI 27 to 40)
  3. Contraindications
    1. Abnormal gastrointestinal motility
    2. Altered Gastrointestinal Anatomy (e.g. Esophageal Strictures)
    3. Pregnancy
    4. Caution in GERD and Peptic Ulcer Disease
  4. Mechanism
    1. Considered a medical device (lower efficacy threshold for approval than medications)
    2. Capsule contains thousands of cellulose hydrogel beads and citric acid
    3. Three capsule dose (taken with water) expands in Stomach and proximal Small Intestine
      1. Increased bulk reduces Stomach capacity for additional intake
      2. Increases satiety
    4. Particles are not absorbed (passed unchanged, unmetabolized into stool)
  5. Dosing
    1. Plenity 3 capsules with 16 ounces water taken 20-30 min before lunch and before dinner
    2. Discontinue use if insignificant weight loss at 2 months
  6. Cost
    1. Estimated at $100 per month
  7. Adverse Effects
    1. Gastrointestinal (e.g. Flatulence, Abdominal Pain, Abdominal Bloating) in 40% of patients
  8. Efficacy
    1. In 6 months of taking medication, results in 2% greater weight loss than Placebo
    2. Similar weight loss to Orlistat, but less weight loss than other medications (e.g. Phentermine, Qsymia)
  9. Drug Interactions
    1. May interfere with absorption of other medications
  10. References
    1. (2020) Presc Lett 28(1): 3
    2. Greenway (2019) Obesity 27(2):205-216 +PMID:30421844 [PubMed]
    3. Sewell (2022) Am Fam Physician 105(3): 309-10 [PubMed]

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree