Endocrinology Book



Aka: Plenity
  1. See Also
    1. Obesity Management
  2. Indications
    1. Obesity (BMI 27 to 40)
  3. Contraindications
    1. Abnormal gastrointestinal motility
    2. Altered Gastrointestinal Anatomy
  4. Mechanism
    1. Considered a medical device
    2. Capsule contains thousands of cellulose hydrogel beads
    3. 3 capsule dose (taken with water) expands in Stomach and reduces Stomach capacity for additional intake
    4. Particles are not absorbed (passed unchanged, unmetabolized into stool)
  5. Dosing
    1. Plenity 3 capsules with 16 ounces water taken 20-30 min before lunch and before dinner
    2. Discontinue use if insignificant weight loss at 2 months
  6. Cost
    1. Estimated at $100 per month
  7. Adverse Effects
    1. Gastrointestinal (e.g. Flatulence, Abdominal Bloating)
  8. Efficacy
    1. In 6 months of taking medication, results in 2% greater weight loss than Placebo
    2. Similar weight loss to Orlistat, but less weight loss than other medications (e.g. Phentermine, Qsymia)
  9. References
    1. (2020) Presc Lett 28(1): 3
    2. Greenway (2019) Obesity 27(2):205-216 +PMID:30421844 [PubMed]

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