//fpnotebook.com/
Medications Associated with Weight Gain
Aka: Medications Associated with Weight Gain, Medications that Exacerbate Obesity
- See Also
- Orlistat (Xenical)
- Lorcaserin (Belviq)
- Phentermine (Ionamin, Fastin)
- Phentermine and Topiramate (Qsymia, Qnexa)
- Obesity
- Obesity in Children
- Obesity Evaluation
- Obesity Measurement (or Obesity Screening)
- Obesity Risk (or Obesity Comorbid Conditions)
- Obesity Management
- Obesity Medication
- Dietary Supplements in Obesity
- Exercise in Obesity
- Obesity Resources
- Preparations: Endocrine Agents
- Diabetes medications
- Most weight gain
- Insulin (associated with 8-15 weight gain)
- Sulfonylureas (e.g. Glyburide, Glipizide, associated with 5 pound weight gain)
- Thiazolidinediones (e.g. Pioglitazone/Actos, associated with 5 pound weight gain)
- Meglitinides
- Least weight gain
- Gliptins (DPP-4 Inhibitor, such as Sitagliptin)
- Glimepiride
- Weight loss
- GLP-1 Agonist (e.g. Liraglutide, exanitide)
- Alpha-glucosidase Inhibitor (e.g. Acarbose, Precose)
- Glucophage (Metformin)
- Pramlintide (Symlin)
- Other endocrine agents associated with weight gain
- Tamoxifen
- Steroid hormones
- Glucocorticoids and Corticosteroids
- Progestational steroids
- Medications: Psychotropics
- Miscellaneous agents associated with weight gain
- Phenothiazines
- Mood Stabilizers
- Most weight gain
- Lithium
- Least weight gain
- Oxcarbazepine (Trileptal)
- Selective Serotonin Reuptake Inhibitors (SSRI)
- Weight gain is associated with Histamine H1 receptor blockade
- Most weight gain
- Mirtazapine (Remeron, averages 6 pound weight gain)
- Paroxetine (Paxil, averages 6 pound weight gain)
- Least weight gain or weight loss
- Fluoxetine (Prozac)
- Sertraline (Zoloft)
- Citalopram (Celexa) or Escitalopram (Lexapro)
- Venlafaxine (Effexor) or Desvenlafaxine (Pristiq)
- Weight loss
- Bupropion (Wellbutrin, averages 6 pound weight loss)
- Monoamine Oxidase Inhibitors
- Most weight gain
- Phenelzine
- Least weight gain
- Tranylcypromine
- Tricyclic Antidepressants
- Most weight gain
- Amitriptyline
- Imipramine
- Nortriptyline
- Least weight gain
- Desipramine
- Protriptyline
- Atypical Antipsychotics
- Most weight gain
- Olanzapine (Zyprexa) has the highest risk (7% weight gain in one third of patients)
- Risperidone
- Clozapine
- Quetiapine (Seroquel)
- Least weight gain (Atypical Antipsychotics)
- Aripiprazole (Abilify)
- Ziprasidone (Geodon)
- Lurasidone (Latuda)
- Paliperidone (Invega)
- Asenapine (Saphris)
- Medications: Neurologic Agents
- Anticonvulsants
- Most weight gain
- Valproic Acid (50% of patients gain 10% body weight)
- Gabapentin (Neurontin, 25% of patients gain 10% body weight)
- Pregabalin (Lyrica)
- Carbamazepine (Tegretol)
- Least weight gain
- Lamotrigine (Lamictal)
- Levetiracetam (Keppra)
- Phenytoin (Dilantin)
- Associated with weight loss
- Topiramate (may cause up to 15 lb weight loss in 6 months)
- Zonisamide (may cause up to 15 lb weight loss in 6 months)
- Felbamate (Felbatol)
- Medications: Cardiovascular Agents
- Antihypertensives
- Most weight gain
- Alpha adrenergic blockers (consider Doxazosin instead)
- Beta adrenergic blockers (esp. Propranolol) - less with selective Beta Blockers
- Calcium Channel Blockers (felodipine, Nifedipine)
- Least weight gain
- ACE Inhibitors
- Angiotensin Receptor Blockers
- Preparations: Miscellaneous
- Highly Active Antiretroviral Therapy
- Diphenhydramine (Benadryl)
- References
- Erlandson (2016) Am Fam Physician 94(5): 361-8 [PubMed]
- Malone (2005) Ann Pharmacother 39(12): 2046-55 [PubMed]