Endocrinology Book


Endocrine Medications in Pregnancy

Aka: Endocrine Medications in Pregnancy
  1. See Also
    1. Medications in Pregnancy
    2. Gestational Diabetes
  2. Background
    1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
      1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
      2. Although FDA Pregnancy Categories are no longer FDA designated, they are included here
        1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
  3. Category: Class A (No risk in controlled human studies)
    1. Dessicated Thyroid (Armour Thyroid)
    2. Levothyroxine (T4 or Synthroid)
    3. Liothyronine (T3 or Cytomel)
  4. Category: Class B (No risk in controlled animal studies)
    1. Acarbose (Precose)
    2. Calcitonin
    3. Insulin
    4. Metformin (Glucophage)
    5. Prednisone
    6. Prednisolone
  5. Category: Class C (Small risk in controlled animal studies)
    1. Acetohexamide
    2. Beclomethasone
    3. Betamethasone
    4. Bromocriptine
    5. Chlorpropamide (Diabinase)
    6. Dexamethasone
    7. Glipizide (Glucotrol)
    8. Glyburide (Micronase or DiaBeta)
    9. Triamcinolone
  6. Category: Class D (Strong evidence of risk to the human fetus)
    1. Lynestrenol
    2. Medroxyprogesterone
    3. Methimazole
    4. Propylthiouracil (preferred over Methimazole)
    5. Tamoxifen
    6. Tolbutamide (Orinase)
  7. Category: Class X (Very high risk to the human fetus)
    1. Clomiphene (Clomid)
    2. Danazol
    3. Diethylstilbesterol (DES)
    4. Estrogens (all)
    5. Iodide I-131
    6. Leuprolide (Leupron)
    7. Norethindrone
    8. Norethynodrel
    9. Norgestrel
    10. Oral Contraceptives
  8. References
    1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
    2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]

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