Endocrinology Book


Growth Hormone Deficiency

Aka: Growth Hormone Deficiency, GH Deficiency, Somatotropin Deficiency
  1. See Also
    1. Short Stature
    2. Hypopituitarism
    3. Pituitary Gland
  2. Epidemiology
    1. Incidence: 1 in 3,000 to 9,000
  3. Causes
    1. Congenital
    2. Acquired
      1. Head Trauma
      2. CNS Infection
      3. Birth Trauma
      4. Cranial irradiation
  4. Signs: Congenital GH Deficiency (newborns)
    1. Normal size at birth
      1. Subsequently falls off height growth curve
      2. Weight for age is preserved
    2. Episodic Hypoglycemia
    3. Prolonged Neonatal Jaundice
    4. Microphallus
    5. Midline craniofacial abnormalities
  5. Signs: Adults
    1. Fatigue
    2. Decreased Muscle mass and strength
    3. Increased visceral fat
    4. Premature atherosclerosis
  6. Imaging
    1. Bone Age Film
      1. Delayed Bone Age
    2. Brain MRI
  7. Labs (in Consultation with pediatric endocrinology)
    1. Screening
      1. Insulinlike Growth Factor 1 (IGF-1)
      2. Insulinlike Growth Factor binding Protein 3
    2. Diagnosis
      1. Negative Growth Hormone provocation test
      2. Pituitary Function Tests
  8. Management
    1. Pediatric Endocrinology referral
    2. Recombinant Growth Hormone injections daily
  9. References
    1. (2000) J Clin Endocrinol Metab 92(3): 804-10 [PubMed]
    2. Barstow (2015) Am Fam Physician 92(1): 43-50 [PubMed]

Somatotropin deficiency (C0271561)

Definition (NCI) Abnormally low levels of circulating somatotropin.
Concepts Disease or Syndrome (T047)
SnomedCT 302867007, 154702001, 44008002, 397827003
Italian Deficit di ormone somatotropo
Japanese 成長ホルモン欠乏症, セイチョウホルモンケツボウショウ
English Somatotropin deficiency, GHD - Growth hormon deficiency, growth hormone insufficiency, growth hormone deficiency, hormone growth deficiency, deficiency growth hormone, somatotropin deficiency, ghd, growth hormones insufficiency, Somatotropin Deficiency, GHD, STH deficiency, Growth hormone deficiency, Growth hormone insufficiency, GHD - Growth hormone deficiency, Growth hormone deficiency (disorder), Somatotropin deficiency (disorder), deficiency; growth hormone, growth hormone; deficiency, Growth hormone deficiency, NOS, Somatotropin deficiency, NOS
Czech Deficit růstového hormonu
Hungarian Növekedési hormon hiány
Spanish deficiencia de hormona del crecimiento, insuficiencia de hormona del crecimiento, deficiencia de hormona del crecimiento (trastorno), deficiencia de STH, deficiencia de hormona de crecimiento (trastorno), deficiencia de hormona de crecimiento, deficiencia de somatotrofina (trastorno), deficiencia de somatotrofina, déficit de STH, déficit de hormona de crecimiento, déficit de hormona somatotrófica, déficit de somatotrofina, Deficiencia de hormona del crecimiento
Dutch deficiëntie; groeihormoon, groeihormoon; deficiëntie, groeihormoondeficiëntie
Portuguese Deficiência da hormona do crescimento
French Déficit en hormone de croissance
German Wachstumshormonmangel
Derived from the NIH UMLS (Unified Medical Language System)

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