Otolaryngology Book

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Vertigo Caused by Medication

Aka: Vertigo Caused by Medication, Medication Causes of Vertigo, Drug-Induced Vertigo
  1. See Also
    1. Vertigo Causes
  2. Background
    1. Medications are responsible for 23% of persistent Dizziness in elderly patients
      1. Maarsingh (2010) Ann Fam Med 8(3): 196-205 [PubMed]
    2. Polypharmacy with more than 5 medications increases the Dizziness risk
      1. Tinetti (2000) Ann Intern Med 132(5): 337-44 [PubMed]
  3. Causes: Cardiovascular Agents
    1. Class Ia Antiarrhythmics (Quinidine, Imipramine, Amiodarone, Disopyramide)
    2. Antihypertensives (esp. Beta Blockers)
    3. Diuretics (e.g. Lasix)
    4. Digoxin
    5. Nitroglycerin
  4. Causes: Endocrine Agents
    1. Antithyroid Drug
    2. Oral Hypoglycemic Agents (esp. SGLT2 Inhibitors such as Invokana)
  5. Causes: Hematologic Agents
    1. Salicylates or Aspirin (Ototoxicity)
    2. Dipyridamole (e.g. Aggrenox)
  6. Causes: Infectious Disease Agents
    1. Amantadine
    2. Aminoglycosides (Ototoxicity)
    3. Quinolones (e.g. Ciprofloxacin)
  7. Causes: Neurologic Agents
    1. Antidementia agents (e.g. Namenda)
    2. Antiparkinsonism Medications (e.g. Sinemet, Mirapex, Cogentin, Amantadine)
    3. Anticonvulsants (typically at toxic levels)
      1. Dilantin
      2. Phenobarbital
      3. Primidone
  8. Causes: Psychiatric agents
    1. Antidepressants
    2. Benzodiazepines
    3. Lithium
  9. Causes: Miscellaneous
    1. Alcohol
    2. Hydroxychloroquine (Ototoxicity)
    3. Phosphodiesterase Inhibitors (e.g. Viagra, Cialis, Levitra)
    4. Anticholinergic Agents
      1. See Anticholinergic Agent
      2. Antihistamines
      3. Skeletal Muscle Relaxants (e.g. Flexeril)
      4. Urinary Antispasmodics (e.g. Ditropan)
  10. References
    1. Muncie (2017) Am Fam Physician 95(3): 154-62 [PubMed]
    2. Shoair (2011) Otolaryngol Clin North Am 44(2): 455-71 [PubMed]

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