Otolaryngology Book


Ototoxic Drug

Aka: Ototoxic Drug, Ototoxic Medication, Ototoxicity
  1. Causes: Medications
    1. Analgesics
      1. Aspirin (>2.7 g/day) and other Salicylates
      2. NSAIDs
      3. Acetaminophen
      4. Sulfasalazine (Azulfidine)
    2. Antibiotics
      1. Aminoglycosides
        1. Starts with Tinnitus and rapidly progresses to Hearing Loss
        2. Ototoxicity symptoms are permanent if last >2-3 weeks after stopping the Aminoglycoside
      2. Streptomycin
      3. Vancomycin
      4. Erythromycin (dose >2 g/day) and other Macrolides
      5. Chloramphenicol
      6. Doxycycline or Minocycline (transient vestibular toxicity)
      7. Imipenem-Cilastin (Primaxin)
      8. Linezolid (Zyvox)
      9. Sulfonamide
      10. Fluoroquinolones
      11. Voriconazole
      12. Amphoteracin B
      13. Ganciclovir
      14. Ribavirin
    3. Loop Diuretics (especially at high dose with rapid infusion)
      1. Ethacrynic Acid
      2. Furosemide (Lasix)
    4. Antineoplastic
      1. Cisplatin
      2. Vincristine and other Vinca Alkaloids
      3. Nitrogen Mustard
      4. Methotrexate
      5. Etoposide
      6. Protein kinase inhibitor
    5. Other medications
      1. Quinine
      2. Chloroquine
      3. Mefloquine
      4. PDE5 Inhibitors (e.g. Sildenafil or Viagra)
      5. Caffeine
      6. Atorvastatin (Lipitor)
      7. Bupropion (Wellbutrin)
      8. Risedronate (Actonel)
      9. Verenicline (Chantix)
  2. Causes: Ilicit Drugs and Poisonings
    1. Heavy metal Poisoning
      1. Mercury Poisoning
      2. Lead Poisoning
    2. Occupational exposures
      1. Toluene
      2. Styrene
    3. Ilicit Drugs
      1. Ecstasy
  3. References
    1. Cianfrone (2011) Eur Rev Med Pharmacol Sci 15(6): 601-36 [PubMed]
    2. Seligmann (1996) Drug Saf 14(3): 198-212 [PubMed]

Ototoxicity (C0235280)

Concepts Injury or Poisoning (T037)
SnomedCT 9062008
English OTOTOXICITY, ototoxicity, Ototoxicity, Ototoxicity (disorder), Ototoxicity, NOS
Italian Ototossicità
Japanese 聴器毒性, チョウキドクセイ
Portuguese OTOTOXICIDADE, Ototoxicidade
Spanish OTOTOXICIDAD, ototoxicidad (trastorno), ototoxicidad, Ototoxicidad
French OTOTOXICITE, Ototoxicité
German OTOTOXIZITAET, Ototoxizitaet
Czech Ototoxicita
Hungarian ototoxicitas
Dutch ototoxiciteit
Derived from the NIH UMLS (Unified Medical Language System)

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