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C1 Human Esterase Inhibitor
Aka: C1 Human Esterase Inhibitor, C1 Antagonist, C1 Inhibitor, Berinert
- See Also
- Angioedema
- Bradykinin Receptor Antagonist
- Indications
- Severe, airway compromising Angioedema
- Hereditary Angioedema (treatment of choice)
- ACE InhibitorAngioedema (may be effective)
- Dose
- Berinert 20 IU/kg IV for 1 dose
- Cost: $3000 per dose
- Adverse Effects
- Headache (common)
- Nausea (common)
- Dizziness
- Fever
- Local skin reaction and Rash
- Flu-like symptoms
- Hypersensitivity Reaction (uncommon)
- Thrombotic event, especially at doses higher than recommended (uncommon)
- References
- (2015) Lexicomp, accessed online 4/9/2015
- Farkas (2007) J Allergy Clin Immunol 120(4):941-7 +PMID:17761272 [PubMed]