Otolaryngology Book

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C1 Human Esterase Inhibitor

Aka: C1 Human Esterase Inhibitor, C1 Antagonist, C1 Inhibitor, Berinert, Plasma-Derived C1 Esterase Inhibitor
  1. See Also
    1. Angioedema
    2. Bradykinin Receptor Antagonist
  2. Indications
    1. Severe, airway compromising Angioedema
      1. Hereditary Angioedema (prophylaxis and treatment of choice)
      2. Not found effective in ACE InhibitorAngioedema
  3. Background
    1. Human plasma-derived C1-INH concentrate
    2. Pasteurized and nanofiltered plasma sample
    3. In Hereditary Angioedema, C1 esterase inhibitor is deficient or non-functional
      1. C1 Esterase Inhibitor suppresses the Classical Complement Pathway (C1 to C3 activation)
      2. C1 Esterase inhibitor also suppresses blood Coagulation Factors (Factor XII and plasma Kallikrein)
        1. Deficiency results in increased bradykinin (vasoactivity) and increased tissue edema
  4. Dose: Hereditary Angioedema Prophylaxis
    1. Adults and Teens: 60 IU/kg SQ twice weekly (every 3-4 days)
    2. Reduces episodes of Angioedema by 95%
  5. Dose: Acute Management
    1. Berinert 20 IU/kg IV for 1 dose
    2. Cost: $3000 per dose
  6. Adverse Effects
    1. Headache (common)
    2. Nausea (common)
    3. Dizziness
    4. Dysgeusia
    5. Fever
    6. Local skin reaction and Rash
    7. Flu-like symptoms
    8. Hypersensitivity Reaction (uncommon)
    9. Thrombotic event, especially at doses higher than recommended (uncommon)
  7. References
    1. (2015) Lexicomp, accessed online 4/9/2015
    2. Lovecchio (2021) Crit Dec Emerg Med 31(10): 24
    3. Farkas (2007) J Allergy Clin Immunol 120(4):941-7 +PMID:17761272 [PubMed]

C1 inhibitor (Human) (C2366367)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH C469952
English C1 INHIBITOR (HUMAN), C1 INHIBITOR, C1 inhibitor (Human), HUMAN C1-ESTERASE INHIBITOR, C1-Esterase Inhibitor, Human, Plasma Protease C1 Inhibitor, C1-Inhibiting Factor, Human C1-Esterase Inhibitor, C1 Inhibitor (Human), C1s inhibitor, human, C1s-INH protein, human, complement C1s inhibitor, human
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Berinert (C2723788)

Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
English Berinert
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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