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Pyoderma Gangrenosum
Aka: Pyoderma Gangrenosum
- See Also
- Pathergy
- Epidemiology
- Rare
- Pathophysiology
- Neutrophilic dermatosis
- Also occurs in Behcet Disease and Sweet Syndrome
- Neutrophils release elastase and other enzymes that result in skin breakdown
- Symptoms
- Painful Pustules and ulcers that form on the legs, buttocks, Abdomen and face in response to minor Skin Trauma
- Signs
- Lesion characteristics
- Initial
- Hemorrhagic, red Pustule or painful, tender Nodule
- Next
- Lesion ulcerates
- Ulcer has irregular, raised, undermined border and advances peripherally
- Ulcer base with exudate that is pustular and hemorrhagic
- Necrotic eschar may form
- Next
- Ulcer heals with thin, atrophic scar
- Distribution (in order of most common to least common)
- Legs
- Buttocks
- Abdomen
- Face
- Pathergy
- See Pathergy Test
- Blistering and ulceration in response to minor Trauma
- Also seen with Behcet Disease
- Associated Conditions
- Inflammatory Bowel Disease (e.g. Crohn's Disease, Ulcerative Colitis)
- Arthritis
- Hematologic Malignancy (e.g. Multiple Myeloma, Leukemia)
- Hepatitis
- Differential Diagnosis
- See Skin Ulcer
- References
- Fitzpatrick (1992) Color Atlas and Synopsis of Clinical Dermatology
- Jhun and DeClerck in Herbert (2015) EM:Rap 15(8): 19-20
- Heiner (2015) Ann Emerg Med 66(2):115-8 [PubMed]