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Drug-Induced Pemphigus
Aka: Drug-Induced Pemphigus, Drug-Triggered Pemphigus
- See Also
- Bullous Disease
- Pemphigus
- Mechanism of Drug-Induced Pemphigus
- Sulfhydryl groups lyse disulfide bonds
- Results in Blister formation
- Causes of Drug-Induced Pemphigus
- D-Penicillamine (5% Incidence with Penicillamine)
- Captopril
- Signs of Drug-Induced Pemphigus
- Pemphigus follows medication use of >2 month duration
- Similar to Superficial Pemphigus (Pemphigus Foliaceus)
- Most cases are mild
- Differential Diagnosis of Drug-Induced Pemphigus
- Erythema Multiforme
- Drug-Triggered Pemphigus (unmasks Pemphigus Vulgaris)
- Rifampin
- Penicillin
- Cephalexin
- Progesterone
- Gold
- Piroxicam
- Phenobarbital
- Course
- Drug-Induced Pemphigus
- Remits with stopping medication in 40-50% of cases
- May follow severe course in some cases
- Drug-Triggered Pemphigus
- Does not remit
- Follows course of Pemphigus Vulgaris
- References
- Habif (1996) Clinical Dermatology, Mosby, p. 512
- Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]
- Rye (1997) Am Fam Physician 55(8):2709-18 [PubMed]