Cardiovascular Medicine Book


Creatine Phosphokinase

Aka: Creatine Phosphokinase, Creatine Kinase, Creatine Phosphotransferase, CPK, CK-MB, CK-MM, CK-BB
  1. See Also
    1. Serum Cardiac Markers
  2. Physiology
    1. Transferase class enzyme activated by Magnesium
    2. Catalyzes ATP energy storage as phosphocreatine
    3. Phosphocreatine stored in muscle and brain
    4. Phosphocreatine keeps ATP constant at Exercise start
  3. Increased
    1. Myocardial Infarction
    2. Myocarditis
    3. Rhabdomyolysis
    4. Myositis
    5. Crush injury or Trauma
    6. Dermatomyositis or Polymyositis
    7. Muscular Dystrophy
    8. Myxedema (Hypothyroidism)
    9. Seizure
    10. Malignant Hyperthermia
    11. Intramuscular Injections
    12. Cerebrovascular Accident
    13. Pulmonary Infarction
    14. Pulmonary Embolus
    15. Acute Aortic Dissection
    16. Vigorous Exercise
      1. CPK levels increase with common exertional activities (e.g. >20x normal at 1 day after marathon)
      2. Siegel (1981) JAMA 246(18): 2049-51 +PMID: 7288991 [PubMed]
      3. Kenney (2012) Muscl Nerve 45(30: 356-62 +PMID:22334169 [PubMed]
      4. Clarkson (2006) Med Sci Sports Exerc 38(4): 623-7 +PMID:16679975 [PubMed]
  4. Isoenzymes:
    1. MB: Heart
    2. MM: Skeletal muscle
    3. BB:
      1. Brain
      2. Bowel infarction
      3. Neoplasm (Prostate, GI, Breast, Ovary, Lung, Brain)
  5. Protocol: Acute Coronary Syndrome Evaluation (listed for historical reasons)
    1. Older protocol - replaced in United States with Troponin
    2. Obtain Serial CPK every 6 hours for total of 3 values
    3. Fractionate to CK-MB only if CPK increased
    4. CK-MB >5% of total CPK suggests Myocardial Infarction

Creatine Kinase (C0010287)

Definition (NCI) An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.
Definition (MSH) A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D003402
SnomedCT 75828004
LNC LP15510-8, MTHU006937
English ADP Phosphocreatine Phosphotransferase, ATP Creatine Phosphotransferase, Creatine Kinase, Creatine Phosphokinase, Creatine Phosphotransferase, ATP, Kinase, Creatine, Phosphocreatine Phosphotransferase, ADP, Phosphokinase, Creatine, Phosphotransferase, ADP Phosphocreatine, Phosphotransferase, ATP Creatine, creatine kinase, ATP:creatine N-phosphotransferase, Creatine Kinase [Chemical/Ingredient], creatine kinase (CK), creatine phosphokinase (CPK), creatine phosphokinase, Phosphocreatine Kinase, ATP:Creatine N-Phosphotransferase, Creatine Phosphotransferase, CPK, CK, Adenosine Triphosphate-Creatine Transphosphorylase, ATP:Creatine Phosphotransferase, Creatine kinase, Creatine phosphokinase, CK - Creatine kinase, CPK - Creatine phosphokinase, Creatine kinase (substance)
Swedish Kreatinkinas
Czech kreatinfosfokinasa, kreatinkináza, kreatinkinasa
Finnish Kreatiinikinaasi
Japanese クレアチンキナーゼ, クレアチンホスホキナーゼ, ローマン酵素
Italian ADP fosfocreatina fosfotransferasi, ATP creatina fosfotransferasi, Creatina fosfochinasi, Creatinchinasi
Polish Fosfokinaza kreatynowa, Kinaza fosfokreatynowa, Kinaza kreatynowa
Portuguese Creatinoquinase, Creatina Fosfoquinase, Creatina Quinase
Spanish creatina cinasa (sustancia), creatina cinasa, creatina fosfocinasa, creatincinasa, creatinquinasa, Creatina Fosfoquinasa, Creatina Quinasa
French CPK, Creatine kinase, ATP créatine N-phosphotransférase, Créatine phosphokinase
German Creatin-Kinase, Creatinkinase-Isoenzyme, Creatinkinase-Isozyme, Creatinphosphokinase, Kreatinase-Isoenzyme, Kreatinase-Isozyme, Kreatinase, Kreatinphosphokinase, Creatinkinase, Kreatinkinase, Kreatinkinase-Isoenzyme
Derived from the NIH UMLS (Unified Medical Language System)

PIK3C2A gene (C1418571)

Concepts Gene or Genome (T028)
English C2-CONTAINING PHOSPHATIDYLINOSITOL KINASE, PIK3C2A, PHOSPHATIDYLINOSITOL 3-KINASE, CLASS 2, ALPHA, CPK, PI3K-C2alpha, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha, PIK3C2A gene
Derived from the NIH UMLS (Unified Medical Language System)

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