II. Pathophysiology

  1. Coxiella Burnetii is an Obligate Intracellular Bacteria
  2. Transmission
    1. Exposure to farm animals (esp. cattle, goats, sheep)
    2. Typically via aerosolized animal feces, contaminated soil or unpasteurized milk
    3. Tick Borne Illness transmission occurs, but is rare
  3. Incubation
    1. Three weeks (ranges from 9-40 days)

III. Symptoms

  1. Flu-like symptoms
    1. Fever
    2. Malaise
    3. Headache
    4. Myalgias
    5. Arthralgias
  2. Respiratory symptoms
    1. Dry cough
    2. Pleuritic Chest Pain
  3. Gastrointestinal symptoms
    1. Nausea
    2. Vomiting
    3. Diarrhea

IV. Complications

  1. Atypical Pneumonia
  2. Acute Respiratory Distress Syndrome (ARDS)
  3. Granulomatous Hepatitis
  4. Endocarditis
  5. Vascular Infections

V. Resources

VI. References

  1. Black, Martin, DeVos (2018) Crit Dec Emerg Med 32(8): 3-12
  2. Nordurft-Froman and DeVos (2022) Crit Dec Emerg Med 36(4): 4-15

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Ontology: Coxiella burnetii (C0010240)

Definition (NCI_CDISC) Any bacterial organism that can be assigned to the species Coxiella burnetii.
Definition (NCI) A species of aerobic, Gram negative, coccobacilli shaped bacteria in the phylum Proteobacteria. This species is obligately intracellular, sporeforming, acidophilic, pleomorphic and catalase positive. C. burnetti is pathogenic, being the causative agent of Q fever.
Definition (MSH) A species of gram-negative bacteria that grows preferentially in the vacuoles of the host cell. It is the etiological agent of Q FEVER.
Definition (CSP) species of gram negative bacteria that grows preferentially in the vacuoles of the host cell; etiologic agent of Q fever; historically classified within the Rickettsiales order, is now taxonomically placed in the Legionellales order, Coxiellaceae family.
Concepts Bacterium (T007)
MSH D016997
SnomedCT 22533000
LNC LP16682-4, MTHU010909
Swedish Coxiella burnetii
Czech Coxiella burnetii
Finnish Coxiella burnetii
English burnetii coxiella, coxiella burnetii, Coxiella burnetii (Derrick 1939) Philip 1948, Rickettsia burneti, Rickettsia diaporica, COXIELLA BURNETII, Coxiella burnetii (organism), Coxiella burnetii
Polish Coxiella burnetii
Norwegian Coxiella burnetii
Spanish Coxiella burnetii (organismo), Coxiella burnetii
French Coxiella burnetii
German Coxiella burnetii
Italian Coxiella burnetii
Dutch Coxiella burnetii, Rickettsia burnetii
Portuguese Coxiella burnetii

Ontology: Q Fever (C0034362)

Definition (NCI) A bacterial infection caused by Coxiella burnetii. It is transmitted to humans by the inhalation of infected air particles or contact with fluids and feces of infected animals. Signs and symptoms include the abrupt onset of fever, headache, myalgias, and weakness.
Definition (MSH) An acute infectious disease caused by COXIELLA BURNETII. It is characterized by a sudden onset of FEVER; HEADACHE; malaise; and weakness. In humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals (ANIMALS, DOMESTIC).
Definition (CSP) acute infectious disease caused by Coxiella burnetii; characterized by a sudden onset of fever,headache, malaise, and weakness; in humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals.
Concepts Disease or Syndrome (T047)
MSH D011778
ICD9 083.0
ICD10 A78
SnomedCT 260588007, 86012006, 266205000, 154375001, 186788009
LNC LA10498-6
English Fevers, Q, Q Fevers, Fever, Q, Nine-mile fever, Q-fever (diagnosis), Coxiella burnetii infection, Q-fever, Fevers, Coxiella burnetii, Query Fever, Fevers, Query, Query Fevers, Fever, Query, Coxiella burnetii Fever, Coxiella burnetii Fevers, Fever, Coxiella burnetii, Nine Mile fever, Q Fever [Disease/Finding], fever q, fever query, query fever, q fever, q-fever, Infection due to Coxiella burnetii (disorder), Balkan grippe, Q fever, Infection due to Coxiella burnetii, Abattoir fever, Balkan influenza, Query fever, Q fever (disorder), Q; fever, Balkan; influenza, fever; Q, fever; nine Mile, infection; Coxiella burnetii, influenza; Balkan, nine Mile; fever, Coxiella burnetii; infection, Q fever (disorder) [Ambiguous], Q Fever
Dutch Coxiella burnetii-infectie, Nine Mile-koorts, Balkan; griep, Coxiella burnetii; infectie, Nine Mile; fever, Q; koorts, fever; Nine Mile, griep; Balkan, infectie; Coxiella burnetii, koorts; Q, Koorts, Q-, Q-koorts
German Coxiella burnetii-Infektion, Schlachthausfieber, Q-Fieber
Italian Infezione da Coxiella burnetii, Febbre delle nove miglia, Febbre Q
Spanish Infección por Coxiella burnetti, Fiebre de las nueve millas, Fiebre por Coxiella burnetti, Fiebre de Query, infección por Coxiella Burnetii (trastorno), infección por Coxiella Burnetii, Fiebre Query, fiebre Q (concepto no activo), fiebre Q (trastorno), fiebre Q, fiebre de los mataderos, gripe de los Balcanes, infección por Coxiella burnetii, influenza de lso Balcanes, Fiebre Q
Japanese Q熱リケッチア感染, Q熱, Qネツリケッチアカンセン, Qネツ, 9マイルネツ, 9マイル熱, Q熱, ナインマイル熱, 濠州Q熱, 米国Q熱
Swedish Q-feber
Czech Q-horečka, Infekce způsobená Coxiella burnetti, Devítimílová horečka, Q horečka, horečka Q
French Fièvre de Nine Mile, Fièvre Q, Coxiellose, Fièvre des abattoirs, Fièvre du Queensland, Grippe des Balkans, Infection à Coxiella burnetii, Maladie de Derrick-Burnet
Portuguese Febre das nove milhas, Febre por Coxiella burnetii, Febre de Query, Infecção por Coxiella burnetti, Rickettsiose por Coxiella burnetti, Endocardite por Coxiella burnetii, Febre Query, Febre Q
Finnish Q-kuume
Korean 큐열
Polish Choroba Derricka i Burneta, Gorączka queenslandzka, Gorączka Q
Hungarian Q-láz, Q láz, Coxiella burnetii fertőzés, Nine-mile láz
Norwegian Query-feber, Q-feber, Coxiella burnetii-feber