II. Class

  1. Anti-retroviral agent
  2. Integrase Strand Transfer Inhibitor

III. Mechanism

  1. Integrase Strand Transfer Inhibitor prevents viral DNA from integrating into host DNA
    1. Blocks the integrase enzyme

IV. Indications

  1. Anti-retroviral naive patients
  2. Anti-retroviral experienced patients

V. Preparations

  1. Bictegravir
  2. Raltegravir
    1. Dose: One 400 mg tablet orally twice daily

VI. Efficacy

  1. Drug resistance is common

VII. Adverse Effects: Raltegravir

VIII. Drug Interactions

  1. Minimal

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Cost: Medications

isentress (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
ISENTRESS 400 MG TABLET $22.34 each
ral (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
RALOXIFENE HCL 60 MG TABLET Generic $1.24 each