Indinavir

Aka: Indinavir, Crixivan

II. Mechanism

  1. Protease Inhibitor

III. Efficacy

  1. Very effective in combination with Zidovudine (AZT)

IV. Dosing

  1. Indinavir 600 mg PO tid ($360/month)
  2. Take on empty Stomach
    1. One hour before or 2 hours after a meal
    2. Concurrent food reduces concentration up to 80%
  3. Drink at least 1.5 Liters (50 oz) liquid per day
    1. Drink 150 ml water per hour for 3 hours after dose
    2. Avoids Nephrolithiasis and Interstitial Nephritis

V. Adverse Effects

  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Well tolerated
  3. Indirect Bilirubin elevation in 10% of patients
  4. Nephrolithiasis in 2-3% of patients
  5. Renal Insufficiency
  6. Alopecia
  7. Dry Skin
  8. Xerostomia
  9. Paronychia
  10. Gallstones

VI. Drug Interactions

  1. St. John's Wort
    1. May reduce Indinavir concentrations by 80%
    2. Piscitelli (2000) Lancet 355:547-8 [PubMed]

VII. References

  1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  3. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]

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Related Studies

Ontology: Indinavir (C0376637)

Definition (NCI) A synthetic hydroxyaminopentane amide agent that selectively inhibits the protease of both human immunodeficiency virus 1 and 2. The incorporation of a basic amine into the hydroxyethylene backbone improves its aqueous solubility and its oral bioavailability.
Definition (NCI_NCI-GLOSS) A drug that interferes with the ability of a virus to make copies of itself.
Definition (MSH) A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
Definition (CSP) potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D019469
SnomedCT 108695003, 372529006
LNC LP21311-3, MTHU013846
English Indinavir, indinavir, IDV, Indinavir [Chemical/Ingredient], Compound J, (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-Pentonamide, INDINAVIR, Indinavir (product), Indinavir (substance)
Swedish Indinavir
Czech indinavir
Finnish Indinaviiri
Russian INDINAVIR, ИНДИНАВИР
Polish Indynawir
Japanese インジナァビル, インジナビル
Spanish indinavir (producto), indinavir (sustancia), indinavir, Indinavir
French Indinavir
German Indinavir
Italian Indinavir
Portuguese Indinavir
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Crixivan (C0701105)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D019469
English indinavir sulfate (Crixivan), crixivan, Crixivan
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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