II. Indications

  1. Anti-Retroviral Therapy experienced patients
  2. Resistance (especially K103N) to first-generation NNRTI (Efavirenz or Nevirapine)

IV. Adverse Effects

  1. See NNRTI for class related adverse effects
  2. Rash (20% of patients)
    1. Stop the agent and do not rechallenge
    2. Higher risk in women (30%) than men (18%)
    3. Risk of serious reactions (1-2%)
      1. Stevens-Johnson Syndrome
      2. Toxic Epidermal Necrolysis
      3. Eythema multiforme
  3. Nausea
  4. Peripheral Neuropathy
  5. Hypertension
  6. Hepatotoxicity
  7. Hyperlipidemia

V. Monitoring

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Cost: Medications

intelence (on 1/14/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
INTELENCE 100 MG TABLET $9.37 each
INTELENCE 200 MG TABLET $18.94 each